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Molecules 2013, 18(11), 14228-14240; doi:10.3390/molecules181114228
Article

Targeting C-myc G-Quadruplex: Dual Recognition by Aminosugar-Bisbenzimidazoles with Varying Linker Lengths

 and
*
Laboratory of Medicinal Chemistry, Department of Chemistry, Clemson University, Clemson, SC 29634, USA
* Author to whom correspondence should be addressed.
Received: 7 October 2013 / Revised: 4 November 2013 / Accepted: 8 November 2013 / Published: 18 November 2013
(This article belongs to the Special Issue G-Quadruplexes & i-Motif DNA)
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Abstract

G-quadruplexes are therapeutically important biological targets. In this report, we present biophysical studies of neomycin-Hoechst 33258 conjugates binding to a G-quadruplex derived from the C-myc promoter sequence. Our studies indicate that conjugation of neomycin to a G-quadruplex binder, Hoechst 33258, enhances its binding. The enhancement in G-quadruplex binding of these conjugates varies with the length and composition of the linkers joining the neomycin and Hoechst 33258 units.
Keywords: G-quadruplex; neomycin; Hoechst 33258; oncogenes; FID; C-myc G-quadruplex; neomycin; Hoechst 33258; oncogenes; FID; C-myc
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Ranjan, N.; Arya, D.P. Targeting C-myc G-Quadruplex: Dual Recognition by Aminosugar-Bisbenzimidazoles with Varying Linker Lengths. Molecules 2013, 18, 14228-14240.

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