Special Issue "Cellular and Molecular Mechanisms of Sperm-Egg Interaction"


A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry, Molecular Biology and Biophysics".

Deadline for manuscript submissions: 30 September 2014

Special Issue Editor

Guest Editor
Dr. Kenji Murata
Center for Heal and Environment, University of California, Davis, CA 95616, USA
Website: http://animalscience.ucdavis.edu/faculty/murata/default.htm
E-Mail: kmurata@ucdavis.edu
Interests: sperm-egg binding (cellular recognition); sperm penetration through the egg envelope; alteration of the egg envelope by components of the egg cortical granules to effect a block to polyspermy; modification of the egg envelope to protect and regulate the environment for the developing embryo

Special Issue Information

Dear Colleagues,

The molecular mechanisms of fertilization (i.e., sperm-egg interactions) have been studied for many years using many different species. As a result of these efforts, knowledge of the molecular pathways used by oocytes and spermatozoa at fertilization has increased; however, research on fertilization at the cellular and molecular levels has been limited and/or is fragmentary when compared to the huge diversity of animal species. As such, many questions remain unanswered.

To provide an integrated view of the process of fertilization and to further understand the cellular and molecular mechanisms of sperm-egg interaction, authors are invited to submit manuscripts that will advance the knowledge of the fields of reproduction. Such knowledge may be applied not only to human reproduction and agricultural species, but will also serve to protect endangered species throughout the world. Basic research dealing with the cellular and molecular mechanisms of sperm-egg interactions and early development through hatching in animals, ranging from invertebrates to vertebrate, is applicable.

Dr. Kenji Murata
Guest Editor


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs).


  • egg-coat (called the egg envelope in invertebrates, chorion in fish, and zona pelucida in other species) glycobiology
  • Sperm activation and chemotaxis
  • acrosome reaction and capacitation
  • Structures and functions of the egg-coat
  • male-female interaction and gamete fusion
  • gamete interactions
  • fusion and activation
  • organelles, proteolysis (including hatching), and germ cells in reproduction

Published Papers (4 papers)

by , , , , ,  and
Int. J. Mol. Sci. 2014, 15(9), 15210-15224; doi:10.3390/ijms150915210
Received: 14 July 2014; in revised form: 28 July 2014 / Accepted: 25 August 2014 / Published: 28 August 2014
Show/Hide Abstract | PDF Full-text (3151 KB) | Supplementary Files

by  and
Int. J. Mol. Sci. 2014, 15(8), 13192-13208; doi:10.3390/ijms150813192
Received: 22 April 2014; in revised form: 6 May 2014 / Accepted: 11 July 2014 / Published: 28 July 2014
Show/Hide Abstract | PDF Full-text (4007 KB)

by , , ,  and
Int. J. Mol. Sci. 2014, 15(7), 12972-12997; doi:10.3390/ijms150712972
Received: 5 May 2014; in revised form: 7 June 2014 / Accepted: 24 June 2014 / Published: 22 July 2014
Show/Hide Abstract | PDF Full-text (1245 KB) | HTML Full-text | XML Full-text

by ,  and
Int. J. Mol. Sci. 2014, 15(6), 10652-10668; doi:10.3390/ijms150610652
Received: 9 April 2014; in revised form: 13 May 2014 / Accepted: 30 May 2014 / Published: 13 June 2014
Show/Hide Abstract | PDF Full-text (697 KB) | HTML Full-text | XML Full-text
abstract graphic

Last update: 22 April 2014

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert