Special Issue "Proteasomes and Its Regulators"
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: 31 March 2014
Prof. Dr. Olivier Coux
Centre de Recherches de Biochimie Macromoléculaire (CRBM), CNRS-UMII UMR5237, Universités Montpellier 1 and 2, 1919 route de Mende, 34293 Montpellier cedex 05, France
Interests: proteasome and its regulators; p53 and Cdc25B ubiquitylation and degradation
Prof. Dr. Michael H. Glickman
Department of Biology, Technion-Israel Institute of Technology, Haifa, Israel
Interests: dynamic protein network responses, networks determining protein fate, turnover and homeostasis (proteostasis);Proteasome structure and function; Mechanistic aspects of protein degradation; ubiquitin-proteasome system; Charting the cellular ubiquitin-linkage profile
25 years after its official beginning in the literature, the proteasome is now recognized as a key regulator of cellular homeostasis, critical for the control of all biological processes. Yet, despite the rapid expansion of the scientific fields in which this fascinating complex (or more exactly family of complexes) has been shown to be involved, it is still often viewed by many biologists as a simple garbage can, largely solved and with no more hidden secrets.
With this special topic-focused compilation on “proteasome and its regulators”, freely accessible online from all over the world, we would like to provide to a general audience a large overview of the present state of our knowledge on this fascinating family of complexes. From what is clearly established to the many open questions that remain to be answered, our objective is to assemble a series of reviews or original articles that will constitute together a “proteasome encyclopedia” in which everyone could find up-to-date information in the different issues directly connected to proteasome biology.
We are thus welcoming any manuscript on the evolution, structure, assembly, mechanisms of action, regulation, or relationship to other biological processes, of the proteasome and its regulators.
We look forward to reading your contributions,
Prof. Michael H. Glickman
Prof. Dr. Olivier Coux
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed Open Access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 300 CHF (Swiss Francs). English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Type of Paper: Review
Title: Molecular action of Proteasome regulators: significance for efficient tumor therapy
Authors: Mohamed Hassan 1,2,3
Affiliations: 1 Cancer Institute, University of Mississippi Medical Center, Jackson, MS 39216, USA; 2 Institut National de la Santé et de la Recherche Médicale, U 977, France;
3 Department of Operative Dentistry and Endodontics, Dental Faculty, University of Strasbourg, 67000 Strasbourg, France; E-Mail: firstname.lastname@example.org (M.H.)
Abstract: The structure and function of the proteasome have been intensively studied in the last three decades. Proteasome is multi-subunit protein complex that, in collaboration with ubiquitin, can mediate the regulation of an energy-dependent proteolytic process in eukaryotic cells. Proteosome is an ambitious 2.5-MDa protein degradation system containing a proteolytic core particle and two terminal regulatory particles. The core particle consists of two outer α rings and two inner β rings that finally form seven structurally similar α and β subunits. The inner surface of the core particle is characterized by its catalytic threonine residues that are characterized by their caspase, trypsin and chymotrypsin-like activities. While, the regulatory particles are responsible for the recognition of the polyubiquitylated substrate proteins to mediate consequently their deubiquitylating, unfolding, and translocation into the interior of the core particle for degradation. Thus, the highlight of the mechanistic role of proteasome regulators, both inhibitors and activators, during the course of tumortherapy may help improve the outcome of tumor treatment. In this review, we will focus on the molecular action of proteasome regulators in the modulation of tumor resistance and response to current therapy.
Last update: 10 December 2013