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Biomolecules 2014, 4(3), 827-847; doi:10.3390/biom4030827

The 26S Proteasome and Initiation of Gene Transcription

Department of Biological Chemistry, University of California, Irvine, CA 92697, USA
Author to whom correspondence should be addressed.
Received: 14 April 2014 / Revised: 20 August 2014 / Accepted: 1 September 2014 / Published: 10 September 2014
(This article belongs to the Special Issue Proteasomes and Its Regulators)
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Transcription activation is the foremost step of gene expression and is modulated by various factors that act in synergy. Misregulation of this process and its associated factors has severe effects and hence requires strong regulatory control. In recent years, growing evidence has highlighted the 26S proteasome as an important contributor to the regulation of transcription initiation. Well known for its role in protein destruction, its contribution to protein synthesis was initially viewed with skepticism. However, studies over the past several years have established the proteasome as an important component of transcription initiation through proteolytic and non-proteolytic activities. In this review, we discuss findings made so far in understanding the connections between transcription initiation and the 26S proteasome complex. View Full-Text
Keywords: ubiquitin; E3 ligase; proteasome; transcription; APIS ubiquitin; E3 ligase; proteasome; transcription; APIS

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Durairaj, G.; Kaiser, P. The 26S Proteasome and Initiation of Gene Transcription. Biomolecules 2014, 4, 827-847.

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