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Biomolecules 2014, 4(4), 931-939; doi:10.3390/biom4040931

Inhibitory Effect of b-AP15 on the 20S Proteasome

Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
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Author to whom correspondence should be addressed.
Received: 5 June 2014 / Revised: 5 August 2014 / Accepted: 23 September 2014 / Published: 14 October 2014
(This article belongs to the Special Issue Proteasomes and Its Regulators)
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Abstract

The 26S proteasome is a cellular proteolytic complex containing 19S regulatory particles and the 20S core proteasome. It was reported that the small molecule b-AP15 targets the proteasome by inhibiting deubiquitination of the 19S regulatory particles of the proteasome complex. An investigation of b-AP15 on the 20S proteasome core suggested that this compound can also inhibit the 20S proteasome with a potency equivalent to that found to inhibit the 19S regulatory particles. View Full-Text
Keywords: proteasome inhibitor; b-AP15; 19S regulatory particles proteasome inhibitor; b-AP15; 19S regulatory particles
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Huang, L.; Jung, K.; Chen, C.H. Inhibitory Effect of b-AP15 on the 20S Proteasome. Biomolecules 2014, 4, 931-939.

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