Special Issue "Function and Structure of RNase P in Fungi, Bacteria and Human Cells"
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: closed (31 January 2016)
Prof. Dr. Denis Drainas
Department of Biochemistry, School of Medicine, University of Patras, 1 Asklipiou st., 26504 Rio-Patras, Greece
Website | E-Mail
Interests: RNase P as a target for novel inhibitors; research and development of polyamine-acidic retinoid conjugates for use as antipsoriatic drugs; activation of the ribozyme RNase P for applications in the specialized silencing of gene expression
Ribonuclease P (RNase P) is an essential endonuclease that cleaves the 5' leader sequence of precursor tRNAs during their biogenesis. Almost all forms of RNase P contain a single RNA subunit, and one (in bacteria) or more (in archaea and eukaryotes) protein subunits. In bacteria, and in some archaea, the RNA subunit is a true trans-acting ribozyme, while in eukaryotes it retains traces of catalytic activity. Recently, in higher eukaryotes, a protein only form of RNase P in mitochondria and chloroplasts has been found.
RNase P is inhibited by many different kinds of inhibitors, like, protein synthesis inhibitors, retinoids, arotinoids, porphyrins, porphines, calcipotriol and anthralin. Due to its high diversity it could be served as a suitable target for the development of new drugs in the battle against bacterial drug resistance.
The finding that the minimal substrate requirements for RNase P activity is a structure equivalent to the upper part of a precursor tRNA allowed RNase P to be used as a tool for gene silencing. Endogenous RNase P directed by external guide sequences, or M1 RNA (the RNA subunit of E. coli RNase P) linked to a guide sequence (M1GS), can cleave any target RNA. This methodology makes RNase P an important tool for RNA-mediated therapeutics.
We look forward to reading your contributions,
Prof. Dr. Denis Drainas
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 650 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.