Table of Contents
Molecules, Volume 21, Issue 4 (April 2016)
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Cover Story With its epidemic proportion and an attrition rate approaching 100%, Alzheimer’s disease (AD) is an [...] Read more. With its epidemic proportion and an attrition rate approaching 100%, Alzheimer’s disease (AD) is an extremely frustrating drug discovery field. Unlike many other major diseases, no medicine has been found to cure or even slow the course of AD. Recently, a small ray of hope has broken through the gloomy outcomes associated with AD: the development of the so-called multitarget drugs. These are single molecules which, acting simultaneously on different pharmacological targets of the disease network, are inherently more adequate to confront AD complex brain pathology. In this issue, Maria Laura Bolognesi, University of Bologna, Italy, and colleagues argue in support of a multitarget drug discovery strategy as a powerful way to develop new, effective, anti-AD drugs. At the same time, they also warn that challenges remain and there is much to learn as we embark on this journey to move them from bench to bedside. View the paper