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Molecules 2016, 21(4), 523; doi:10.3390/molecules21040523

Glycyrrhetic Acid Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Vivo

1
Department of Oriental Medicine Resources, Chonbuk National University, 79 Gobongro, Iksan 570-752(1), Korea
2
Department of Pharmacy, College of Pharmacy, Dongduk Woman’s University, 23-1 Wolgok-Dong, SungBuk-Gu, Seoul 136-714, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 25 January 2016 / Revised: 13 April 2016 / Accepted: 14 April 2016 / Published: 22 April 2016
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [2467 KB, uploaded 22 April 2016]   |  

Abstract

Glycyrrhizae Radix (GR) is a Korean traditional herb medicine that is widely used in clinical health care. Glycyrrhetic acid (GA) is an aglycone saponin extracted from GR that has anti-inflammatory, anti-cancer, and anti-viral effects. However, the anti-inflammatory effects of GA in colitis have not been reported. This study investigated the role of GA on ulcerative colitis in a dextran sulfate sodium (DSS)-induced mouse colitis model. DSS-treated mice displayed weight loss and shortened colon length compared with control mice. Mice administered GA showed less weight loss and longer colon length than the DSS-treated group. Interleukin (IL)-6, IL-1β, and tumor necrosis factor-alpha were decreased by GA treatment. GA treatment also reduced DSS-induced microscopic damage to colon tissue. GA regulates the phosphorylation of transcription factors including nuclear factor-kappa B (NF-κB) and IκB alpha, and regulates the expression of cycloxygenase-2 and prostaglandin E2. GA thus showed beneficial effects in a mouse model of colitis, implicating GA might be a useful herb-derived medicine in the treatment of ulcerative colitis. View Full-Text
Keywords: glycyrrhetic acid; ulcerative colitis; dextran sulfate sodium; anti-inflammation glycyrrhetic acid; ulcerative colitis; dextran sulfate sodium; anti-inflammation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Jeon, Y.-D.; Kang, S.-H.; Bang, K.-S.; Chang, Y.-N.; Lee, J.-H.; Jin, J.-S. Glycyrrhetic Acid Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Vivo. Molecules 2016, 21, 523.

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