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Molecules 2016, 21(4), 527; doi:10.3390/molecules21040527

The Effects of Topical Application of Polycal (a 2:98 (g/g) Mixture of Polycan and Calcium Gluconate) on Experimental Periodontitis and Alveolar Bone Loss in Rats

1
The Medical Research Center for Globalization of Herbal Medicine, Daegu Haany University, Gyeongsan 38610, Korea
2
Department of Histology and Anatomy, College of Korean Medicine, Daegu Haany University, Gyeongsan 38610, Korea
3
Department of Preventive Medicine, College of Korean Medicine, Deagu Haany University, Gyeongsan 38610, Korea
4
Clinical Research Division, Korean Institute of Oriental Medicine, Daejeon 34054, Korea
5
ARIBIO, Jecheon 27159, Korea
6
Department of Qigong, College of Korean Medicine, Deagu Haany University, Gyeongsan 38610, Korea
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 29 February 2016 / Revised: 8 April 2016 / Accepted: 18 April 2016 / Published: 22 April 2016
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [7781 KB, uploaded 22 April 2016]   |  

Abstract

The aim of this study was to observe whether Polycal has inhibitory activity on ligation-induced experimental periodontitis and related alveolar bone loss in rats following topical application to the gingival regions. One day after the ligation placements, Polycal (50, 25, and 12.5 mg/mL solutions at 200 μL/rat) was topically applied to the ligated gingival regions daily for 10 days. Changes in bodyweight, alveolar bone loss index, and total number of buccal gingival aerobic bacterial cells were monitored, and the anti-inflammatory effects were investigated via myeloperoxidase activity and levels of the pro-inflammatory cytokines IL-1β and TNF-α. The activities of inducible nitric oxide synthase (iNOS) and lipid peroxidation (MDA) were also evaluated. Bacterial proliferation, periodontitis, and alveolar bone loss induced by ligature placements were significantly inhibited after 10 days of continuous topical application of Polycal. These results indicate that topical application of Polycal has a significant inhibitory effect on periodontitis and related alveolar bone loss in rats mediated by antibacterial, anti-inflammatory, and anti-oxidative activities. View Full-Text
Keywords: alveolar bone loss; anti-bacterial effects; anti-inflammatory; antioxidant; β-glucan; calcium gluconate alveolar bone loss; anti-bacterial effects; anti-inflammatory; antioxidant; β-glucan; calcium gluconate
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Park, S.-I.; Kang, S.-J.; Han, C.-H.; Kim, J.-W.; Song, C.-H.; Lee, S.-N.; Ku, S.-K.; Lee, Y.-J. The Effects of Topical Application of Polycal (a 2:98 (g/g) Mixture of Polycan and Calcium Gluconate) on Experimental Periodontitis and Alveolar Bone Loss in Rats. Molecules 2016, 21, 527.

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