Special Issue "Viruses and miRNAs"
Deadline for manuscript submissions: closed (31 December 2013)
Prof. Dr. Andrew P. Rice
Nancy Chang Professor, Rice Lab - Molecular Virology & Microbiology, One Baylor Plaza, Mail Stop BCM-385, Houston, Texas 77030, USA
Phone: +713 798 5774
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed Open Access monthly journal published by MDPI.
Viruses 2012, 4(9), 1390-1409; doi:10.3390/v4091390
Received: 18 June 2012; in revised form: 28 July 2012 / Accepted: 30 July 2012 / Published: 29 August 2012| Download PDF Full-text (2176 KB) | Download XML Full-text
Viruses 2012, 4(9), 1687-1710; doi:10.3390/v4091687
Received: 31 July 2012; in revised form: 22 August 2012 / Accepted: 3 September 2012 / Published: 21 September 2012| Download PDF Full-text (2594 KB) | Download XML Full-text
Article: miRNA Profiles of Monocyte-Lineage Cells Are Consistent with Complicated Roles in HIV-1 Restriction
Viruses 2012, 4(10), 1844-1864; doi:10.3390/v4101844
Received: 25 July 2012; in revised form: 8 September 2012 / Accepted: 11 September 2012 / Published: 25 September 2012| Download PDF Full-text (526 KB) | Download XML Full-text | Correction
Review: MicroRNAs, Hepatitis C Virus, and HCV/HIV-1 Co-Infection: New Insights in Pathogenesis and Therapy
Viruses 2012, 4(11), 2485-2513; doi:10.3390/v4112485
Received: 31 August 2012; in revised form: 17 October 2012 / Accepted: 18 October 2012 / Published: 26 October 2012| Download PDF Full-text (2164 KB) | Download XML Full-text
Viruses 2013, 5(11), 2659-2678; doi:10.3390/v5112659
Received: 23 September 2013; in revised form: 18 October 2013 / Accepted: 21 October 2013 / Published: 30 October 2013| Download PDF Full-text (410 KB) | Download XML Full-text
Viruses 2013, 5(11), 2690-2703; doi:10.3390/v5112690
Received: 22 September 2013; in revised form: 28 October 2013 / Accepted: 29 October 2013 / Published: 7 November 2013| Download PDF Full-text (920 KB) | Download XML Full-text
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: An Artificial miRNA Derived from the Virulence Modulating Region of Potato Spindle Tuber Viroid Induces Viroid-like Symptoms in Nicotiana Species
Authors: Andy Eamens, Smith, Dennis, Wassenegger and Ming-Bo Wang
Affiliation: Lecturer in Plant Molecular Genetics, School of Environmental & Life Sciences, The University of Newcastle, Callaghan NSW 2308, Australia
Abstract: Potato spindle tuber viroid (PSTVd) is a small non-protein-coding RNA pathogen that can induce disease symptoms in a variety of plants including species of the Solanaceae family. How PSTVd induces symptoms remains to be fully determined but it has been suggested that small RNAs (sRNAs) derived from the virulence modulating region (VMR) may direct RNA silencing of a host gene(s), resulting in symptom development. To test this sRNA-mediated disease model, we expressed VMR sequences as 21 nucleotide (nt) artificial miRNAs (amiRNAs) in Nicotiana tabacum and Nicotiana benthamiana. One of the 21-nt amiRNAs, termed amiR46, which corresponds to nt. 46-66 of the PSTVd genome within the VMR sequence, caused phenotypes that closely resemble PSTVd-induced symptoms, including plant stunting and bushiness, as well as leaf elongation and discolouration. Expression of amiRNAs corresponding to non-PSTVd VMR sequences did not induce any visible phenotype. The severity of the amiR46 phenotype correlated with amiR46 accumulation, indicating a direct effect of the 21-nt sRNA on symptom development. Our results indicate that a single 21-nt sRNA corresponding to the PSTVd VMR is sufficient to induce PSTVd-like symptoms, supporting the involvement of PSTVd sRNA-directed host gene RNA silencing in symptom development.
Keywords: Potato spindle tuber viroid; disease symptoms; small RNA; artificial miRNA; RNA silencing
Last update: 23 October 2013