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Viruses 2013, 5(11), 2690-2703; doi:10.3390/v5112690

Roles of microRNAs in the Hepatitis B Virus Infection and Related Diseases

Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
Author to whom correspondence should be addressed.
Received: 22 September 2013 / Revised: 28 October 2013 / Accepted: 29 October 2013 / Published: 7 November 2013
(This article belongs to the Special Issue Viruses and miRNAs)
View Full-Text   |   Download PDF [920 KB, 12 May 2015; original version 12 May 2015]   |  


The hepatitis B virus (HBV) is a small enveloped DNA virus that belongs to the Hepadnaviridae family. HBV can cause acute and persistent infection which can lead to hepatocellular carcinoma (HCC). MicroRNAs (miRNAs) play a crucial role in the main cellular events. The dysregulation of their expression has been linked to the development of the cancer as well as to viral interference. This chapter will describe the involvement of miRNAs in the case of HBV infection and their implication in the development of the HBV-related diseases.
Keywords: hepatitis B virus; microRNA; hepatocellular carcinoma hepatitis B virus; microRNA; hepatocellular carcinoma
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Thirion, M.; Ochiya, T. Roles of microRNAs in the Hepatitis B Virus Infection and Related Diseases. Viruses 2013, 5, 2690-2703.

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