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Viruses 2012, 4(11), 2485-2513; doi:10.3390/v4112485
Review

MicroRNAs, Hepatitis C Virus, and HCV/HIV-1 Co-Infection: New Insights in Pathogenesis and Therapy

1,2,3,4,†
, 1,2,3,†
, 1,3
 and 1,3,*
Received: 31 August 2012; in revised form: 17 October 2012 / Accepted: 18 October 2012 / Published: 26 October 2012
(This article belongs to the Special Issue Viruses and miRNAs)
View Full-Text   |   Download PDF [2164 KB, uploaded 26 October 2012]
Abstract: MicroRNAs (miRNAs) can exert a profound effect on Hepatitis C virus (HCV) replication. The interaction of HCV with the highly liver-enriched miRNA, miR-122 represents one such unique example of viruses having evolved mechanism(s) to usurp the host miRNA machinery to support viral life cycle. Furthermore, HCV infection can also trigger changes in the cellular miRNA profile, which may ultimately contribute to the outcome of viral infection. Accumulating knowledge on HCV-host miRNA interactions has ultimately influenced the design of therapeutic interventions against chronic HCV infection. The importance of microRNA modulation in Human Immunodeficiency Virus (HIV-1) replication has been reported, albeit only in the context of HIV-1 mono-infection. The development of HCV infection is dramatically influenced during co-infection with HIV-1. Here, we review the current knowledge on miRNAs in HCV mono-infection. In addition, we discuss the potential role of some miRNAs, identified from the analyses of public data, in HCV/HIV-1 co-infection.
Keywords: microRNA; miR-122, exosomes, HCV; hepatitis C virus; hepatitis; antiviral response; HIV-1; HIV-1/HCV co-infection; antagomir; therapeutics microRNA; miR-122, exosomes, HCV; hepatitis C virus; hepatitis; antiviral response; HIV-1; HIV-1/HCV co-infection; antagomir; therapeutics
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Gupta, A.; Swaminathan, G.; Martin-Garcia, J.; Navas-Martin, S. MicroRNAs, Hepatitis C Virus, and HCV/HIV-1 Co-Infection: New Insights in Pathogenesis and Therapy. Viruses 2012, 4, 2485-2513.

AMA Style

Gupta A, Swaminathan G, Martin-Garcia J, Navas-Martin S. MicroRNAs, Hepatitis C Virus, and HCV/HIV-1 Co-Infection: New Insights in Pathogenesis and Therapy. Viruses. 2012; 4(11):2485-2513.

Chicago/Turabian Style

Gupta, Archana; Swaminathan, Gokul; Martin-Garcia, Julio; Navas-Martin, Sonia. 2012. "MicroRNAs, Hepatitis C Virus, and HCV/HIV-1 Co-Infection: New Insights in Pathogenesis and Therapy." Viruses 4, no. 11: 2485-2513.


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