Viruses 2012, 4(9), 1687-1710; doi:10.3390/v4091687
Review

Emerging Themes from EBV and KSHV microRNA Targets

Dhivya Ramalingam † , Philippe Kieffer-Kwon †  and Joseph M. Ziegelbauer* email
HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA † These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 31 July 2012; in revised form: 22 August 2012 / Accepted: 3 September 2012 / Published: 21 September 2012
(This article belongs to the Special Issue Viruses and miRNAs)
PDF Full-text Download PDF Full-Text [2594 KB, uploaded 24 September 2012 17:04 CEST]
Abstract: EBV and KSHV are both gamma-herpesviruses which express multiple viral microRNAs. Various methods have been used to investigate the functions of these microRNAs, largely through identification of microRNA target genes. Surprisingly, these related viruses do not share significant sequence homology in their microRNAs. A number of reports have described functions of EBV and KSHV microRNA targets, however only three experimentally validated target genes have been shown to be targeted by microRNAs from both viruses. More sensitive methods to identify microRNA targets have predicted approximately 60% of host targets could be shared by EBV and KSHV microRNAs, but by targeting different sequences in the host targets. In this review, we explore the similarities of microRNA functions and targets of these related viruses.
Keywords: EBV; KSHV; HHV4; HHV8; miRNAs; microRNAs

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Ramalingam, D.; Kieffer-Kwon, P.; Ziegelbauer, J.M. Emerging Themes from EBV and KSHV microRNA Targets. Viruses 2012, 4, 1687-1710.

AMA Style

Ramalingam D, Kieffer-Kwon P, Ziegelbauer JM. Emerging Themes from EBV and KSHV microRNA Targets. Viruses. 2012; 4(9):1687-1710.

Chicago/Turabian Style

Ramalingam, Dhivya; Kieffer-Kwon, Philippe; Ziegelbauer, Joseph M. 2012. "Emerging Themes from EBV and KSHV microRNA Targets." Viruses 4, no. 9: 1687-1710.

Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert