Special Issue "Biomimetic Receptors and Sensors"
A special issue of Sensors (ISSN 1424-8220).
Deadline for manuscript submissions: 30 June 2013
Prof. Dr. Franz Dickert
Department of Analytical Chemistry, University of Vienna, Währinger Strasse 38, A-1090 Vienna, Austria
Phone: +43 1 4277 52301
Fax: +431 4277 9520
Interests: mass sensitive transducers (QCM, SAW); fluorescence; surface chemistry; host guest chemistry; molecular imprinting
Molecular Recognition is the most dominant challenge of chemistry in the last decades. This strategy can lead to biomimetic receptors, realized by supramolecular chemistry according to J.-M. Lehn. These molecular systems are based on interactions between molecules and ions. In this way innovative receptors can be designed mimicking biological analogues as antibodies and enzymes. These phenomena can be understood according to host-guest chemistry. Synthetic crown ethers e.g. synthesized by C.J. Pedersen show a high selectivity to potassium ions in analogy to the cyclic antibiotic valinomycin. Template-directed syntheses are often used to create synthetic receptors according to biomimetic strategies. These ideas are further developed by molecular imprinting embedding these receptors created by template-directed synthesis into a robust polymer. Furthermore, these processes are based on self-organisation without time-consuming synthesis. These biomimetic coatings can selectively bind both ions and neutral molecules up to complex bioanalytes. SPE leads to cleaning and selective enrichment of analytes. These materials are favourably used as sensitive layers for sensors combined with a variety of transducer principles such as optical, electrochemical and mass-sensitive detection. Analytes are accessible concerning samples of environment, biological/medical applications and process engineering. The analytes cover a wide range from sub-nano-metre for molecules to micro-metre for biological particles.
Prof. Dr. Franz Dickert
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed Open Access monthly journal published by MDPI.
- biomimetic receptors
- supramolecular and host-guest chemistry
- imprinted polymers
- molecule and ion detection
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Type of Paper: Article
Title: Stem Cell Enrichment with Selectin Receptors: Mimicking the pH Environment of Trauma
Authors: Michael J. Mitchell, Thong Cao and Michael R. King
Affiliation: Department of Biomedical Engineering, Cornell University; E-Mail: firstname.lastname@example.org
Abstract: The isolation of hematopoietic stem and progenitor cells (HSPCs) is critical for transplantation therapy and HSPC research, however current isolation techniques are prohibitively expensive and produce variable results. Selectin-coated microtubes have shown promise in isolating HSPCs from bone marrow, but further purification of HSPCs remains challenging. Herein, a biomimetic device for HSPC isolation was developed to mimic the acidic vascular microenvironment during trauma, which can enhance the binding frequency between L-selectin (on HSPCs) and its counter-receptor PSGL-1. PSGL-1 coated microtubes captured HSPCs at increased purity levels under acidic conditions. Dynamic light scattering was utilized as a novel sensor to confirm an L-selectin conformational change under acidic conditions, as previously predicted by molecular dynamics. These results suggest that mimicking the acidic environment of trauma could enhance the clinical isolation of HSPCs.
Type of Paper: Review
Title: Infrared Receptors for Fire Detection in Pyrophilous Insects
Authors: Herbert Bousack, Thilo Kahl, Erik Schneider, Anke Schmitz and Helmut Schmitz
Affiliation: Institute of Zoology, University of Bonn, Poppelsdorfer Schloß, 53115, Bonn, Germany; E-Mail: email@example.com
Abstract: This review will deal with the capability of insects to sense infrared (IR) radiation emitted from forest fires. So far, true IR receptors have only been found in so-called pyrophilous insects which show the behaviour to approach forest fires. In three genera of pyrophilous beetles and one genus of pyrophilous bugs infrared (IR) receptors have been discovered which will be described in some detail. Although IR receptors are very rare in insects, there is strong evidence that receptors have evolved independently in all four genera of IR sensitive insects. From a technical point of view, insect IR receptors can be classified into two classes: bolometer like sensors innervated by thermoreceptors and so-called photomechanic sensors innervated by highly sensitive so-called ciliary mechanoreceptors. Bolometer like receptors were found in the Australian "fire-beetle" Merimna atrata and the Australian "little-ash" beetle Acanthocnemus nigricans. However, these receptors are fundamentally different from each other. On the other hand the photomechanic IR receptors which can be found in jewel beetles of the genus Melanophila and in some pyrophilous species of the flat bug genus Aradus, are very similar. This type of receptor most probably has developed directly from common mechanosensitive bristles (sensilla triochodea). This development, however, most probably happened independently in Melanophila beetles and in few pyrophilous flat bugs of the large genus Aradus. Because the photomechanic IR receptors seem to be promising candidates for the design of IR sensors, the last part of the review will deal with the biomimetic approach to use this class of insect IR receptors to build new uncooled IR sensors for various applications.
Last update: 28 December 2012