Sensors 2014, 14(5), 8605-8632; doi:10.3390/s140508605
Review

Metal Oxide Nanosensors Using Polymeric Membranes, Enzymes and Antibody Receptors as Ion and Molecular Recognition Elements

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Received: 20 February 2014; in revised form: 30 April 2014 / Accepted: 6 May 2014 / Published: 16 May 2014
(This article belongs to the Special Issue Biomimetic Receptors and Sensors)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The concept of recognition and biofunctionality has attracted increasing interest in the fields of chemistry and material sciences. Advances in the field of nanotechnology for the synthesis of desired metal oxide nanostructures have provided a solid platform for the integration of nanoelectronic devices. These nanoelectronics-based devices have the ability to recognize molecular species of living organisms, and they have created the possibility for advanced chemical sensing functionalities with low limits of detection in the nanomolar range. In this review, various metal oxides, such as ZnO-, CuO-, and NiO-based nanosensors, are described using different methods (receptors) of functionalization for molecular and ion recognition. These functionalized metal oxide surfaces with a specific receptor involve either a complex formation between the receptor and the analyte or an electrostatic interaction during the chemical sensing of analytes. Metal oxide nanostructures are considered revolutionary nanomaterials that have a specific surface for the immobilization of biomolecules with much needed orientation, good conformation and enhanced biological activity which further improve the sensing properties of nanosensors. Metal oxide nanostructures are associated with certain unique optical, electrical and molecular characteristics in addition to unique functionalities and surface charge features which shows attractive platforms for interfacing biorecognition elements with effective transducing properties for signal amplification. There is a great opportunity in the near future for metal oxide nanostructure-based miniaturization and the development of engineering sensor devices.
Keywords: ZnO nanostructures; CuO nanostructures; NiO nanostructures; potentiometric nanosensors; biosensors; chemical sensors
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MDPI and ACS Style

Willander, M.; Khun, K.; Ibupoto, Z.H. Metal Oxide Nanosensors Using Polymeric Membranes, Enzymes and Antibody Receptors as Ion and Molecular Recognition Elements. Sensors 2014, 14, 8605-8632.

AMA Style

Willander M, Khun K, Ibupoto ZH. Metal Oxide Nanosensors Using Polymeric Membranes, Enzymes and Antibody Receptors as Ion and Molecular Recognition Elements. Sensors. 2014; 14(5):8605-8632.

Chicago/Turabian Style

Willander, Magnus; Khun, Kimleang; Ibupoto, Zafar H. 2014. "Metal Oxide Nanosensors Using Polymeric Membranes, Enzymes and Antibody Receptors as Ion and Molecular Recognition Elements." Sensors 14, no. 5: 8605-8632.

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