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Sensors 2014, 14(8), 13863-13912; doi:10.3390/s140813863

Bio-Mimetic Sensors Based on Molecularly Imprinted Membranes

Research Institute on Membrane Technology, ITM-CNR, c/o University of Calabria, Via P. Bucci, Cubo 17/C, 87030 Rende (CS), Italy
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Received: 18 April 2014 / Revised: 16 July 2014 / Accepted: 21 July 2014 / Published: 30 July 2014
(This article belongs to the Special Issue Biomimetic Receptors and Sensors)
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Abstract

An important challenge for scientific research is the production of artificial systems able to mimic the recognition mechanisms occurring at the molecular level in living systems. A valid contribution in this direction resulted from the development of molecular imprinting. By means of this technology, selective molecular recognition sites are introduced in a polymer, thus conferring it bio-mimetic properties. The potential applications of these systems include affinity separations, medical diagnostics, drug delivery, catalysis, etc. Recently, bio-sensing systems using molecularly imprinted membranes, a special form of imprinted polymers, have received the attention of scientists in various fields. In these systems imprinted membranes are used as bio-mimetic recognition elements which are integrated with a transducer component. The direct and rapid determination of an interaction between the recognition element and the target analyte (template) was an encouraging factor for the development of such systems as alternatives to traditional bio-assay methods. Due to their high stability, sensitivity and specificity, bio-mimetic sensors-based membranes are used for environmental, food, and clinical uses. This review deals with the development of molecularly imprinted polymers and their different preparation methods. Referring to the last decades, the application of these membranes as bio-mimetic sensor devices will be also reported. View Full-Text
Keywords: molecular recognition; molecular imprinting; molecularly imprinted membranes; biosensors; bio-mimetic sensors molecular recognition; molecular imprinting; molecularly imprinted membranes; biosensors; bio-mimetic sensors
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Algieri, C.; Drioli, E.; Guzzo, L.; Donato, L. Bio-Mimetic Sensors Based on Molecularly Imprinted Membranes. Sensors 2014, 14, 13863-13912.

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