Special Issue "Design of Bioreactor Systems for Tissue Engineering"


A special issue of Processes (ISSN 2227-9717).

Deadline for manuscript submissions: closed (15 February 2014)

Special Issue Editor

Guest Editor
Prof. Dr. Julian Chaudhuri
School of Engineering and Informatics, University of Bradford, Bradford, West Yorkshire, BD7 1DP, UK
Website: http://www.bradford.ac.uk/governance/senior-management-team/
E-Mail: J.Chaudhuri1@bradford.ac.uk
Phone: +01274 234021
Interests: regenerative medicine; tissue engineering; bioreactors; stem cell bioprocessing

Special Issue Information

Dear Colleagues,

This special issue of Processes will consider papers in the general area of Design of Bioreactor Systems for Tissue Engineering. The objective of this issue is to showcase the diversity and advances in research that contributes to developing effective systems for the culture and controlled differentiation of stem cells, or the combination of cells and biomaterials into functional tissue. There are a range of topics that contribute to “bioreactor systems” that include the following: cell culture and differentiation, culture on or in 3D scaffolds, bioprocessing considerations such as scale-up and monitoring and control, bioreactor design, membranes and other perfusion systems, co-culture, adherent or suspension cell culture, mathematical models, in vitro models, nutrient diffusion and mass transfer in 3D, fluid dynamics and shear.

We are particularly interested in receiving manuscripts that integrate biology and engineering research and/or experimental and theoretical studies. We invite researchers and practitioners from all areas of regenerative medicine to submit manuscripts for this important special issue of Processes.

Prof. Dr. Julian Chaudhuri
Guest Editor


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Processes is an international peer-reviewed Open Access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. For the first couple of issues the Article Processing Charge (APC) will be waived for well-prepared manuscripts. English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.


  • cell culture
  • scaffolds
  • bioprocessing
  • scale-up
  • monitoring and control
  • mathematical models
  • stem cell differentiation
  • bioreactor design
  • membranes
  • diffusion and mass transfer

Published Papers (7 papers)

Processes 2014, 2(2), 345-360; doi:10.3390/pr2020345
Received: 22 November 2013; in revised form: 31 January 2014 / Accepted: 21 February 2014 / Published: 31 March 2014
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Processes 2014, 2(2), 333-344; doi:10.3390/pr2020333
Received: 10 December 2013; in revised form: 20 February 2014 / Accepted: 28 February 2014 / Published: 28 March 2014
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Processes 2014, 2(1), 167-179; doi:10.3390/pr2010167
Received: 3 January 2014; in revised form: 7 February 2014 / Accepted: 10 February 2014 / Published: 19 February 2014
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Processes 2014, 2(1), 71-88; doi:10.3390/pr2010071
Received: 13 September 2013; in revised form: 25 November 2013 / Accepted: 20 December 2013 / Published: 10 January 2014
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Processes 2014, 2(1), 34-57; doi:10.3390/pr2010034
Received: 18 September 2013; in revised form: 5 December 2013 / Accepted: 19 December 2013 / Published: 3 January 2014
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Processes 2014, 2(1), 1-11; doi:10.3390/pr2010001
Received: 30 September 2013; in revised form: 20 November 2013 / Accepted: 12 December 2013 / Published: 20 December 2013
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Processes 2013, 1(3), 349-359; doi:10.3390/pr1030349
Received: 22 July 2013; in revised form: 17 October 2013 / Accepted: 20 November 2013 / Published: 18 December 2013
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Type of Paper: Article
Title: Design Criteria for Generating Physiologically Relevant in-vitro Models in Bioreactors
Author: Arti Ahluwalia
Affiliation: Centro Interdipartimentale di Ricerca “E. Piaggio”, Faculty of Engineering, University of Pisa, via Diotisalvi 2, 56125 Pisa, Italy; E-Mail: arti.ahluwalia@centropiaggio.unipi.it
Abstract: In this paper we discuss the basic design requirements for the development of physiologically meaningful in-vitro systems comprising cells, scaffolds and bioreactors, through a bottom up approach. At each step the fluidic and mass transport parameters in biological tissue design are considered, starting from basic questions such as the minimum number of cells required to represent a physiological system and the minimum fluid volume to cell ratio necessary to ensure an adequate nutrient supply to tissues. At the next level we consider the use of three-dimensional scaffolds, which are employed both for regenerative medicine applications and for the study of cells in environments which better recapitulate the physiological milieu. Here the driving need is the rate of oxygen supply which must be maintained at a constant level to ensure normoxia throughout the thickness of a scaffold. Scaffold and bioreactor design are both critical in defining the oxygen profile in a scaffold and are considered together. We also discuss the oxygen-shear stress trade-off by quantifying the levels of mechanical stress required for different types of cells and tissues. Finally the allometric approach for generating multi-tissue systemic models using bioreactors is described.

Last update: 12 February 2014

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