Special Issue "Design of Bioreactor Systems for Tissue Engineering"
A special issue of Processes (ISSN 2227-9717).
Deadline for manuscript submissions: 15 February 2014
Prof. Dr. Julian Chaudhuri
Centre for Regenerative Medicine, Department of Chemical Engineering, University of Bath, Bath BA2 7AY, UK
Phone: +44 1225 386349
Interests: regenerative medicine; tissue engineering; bioreactors; stem cell bioprocessing
This special issue of Processes will consider papers in the general area of Design of Bioreactor Systems for Tissue Engineering. The objective of this issue is to showcase the diversity and advances in research that contributes to developing effective systems for the culture and controlled differentiation of stem cells, or the combination of cells and biomaterials into functional tissue. There are a range of topics that contribute to “bioreactor systems” that include the following: cell culture and differentiation, culture on or in 3D scaffolds, bioprocessing considerations such as scale-up and monitoring and control, bioreactor design, membranes and other perfusion systems, co-culture, adherent or suspension cell culture, mathematical models, in vitro models, nutrient diffusion and mass transfer in 3D, fluid dynamics and shear.
We are particularly interested in receiving manuscripts that integrate biology and engineering research and/or experimental and theoretical studies. We invite researchers and practitioners from all areas of regenerative medicine to submit manuscripts for this important special issue of Processes.
Prof. Dr. Julian Chaudhuri
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Processes is an international peer-reviewed Open Access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. For the first couple of issues the Article Processing Charge (APC) will be waived for well-prepared manuscripts. English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.
- cell culture
- monitoring and control
- mathematical models
- stem cell differentiation
- bioreactor design
- diffusion and mass transfer
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Modelling Cell Motion and Distribution in NASA's Rotating Bioreactor
Authors: Tzu Chieh Chao and Diganta Bhusan Das
Affiliation: Department of Chemical Engineering, Loughborough University, Loughborough LE11 3TU, Leicestershire, UK; E-Mail: D.B.Das@lboro.ac.uk
Abstract: Rotating bioreactor, such as the NASA bioreactor, which was designed by the National Aeronautics and Space Administration (NASA), USA, can be used to mimic micro-gravity conditions and simulate the effects of microgravity on cells growth and behaviour. The cell growth in the bioreactor depends on the nutrient availability which again depends on the non-uniform cell density and distribution within the bioreactor. In this work, we develop a numerical model of suspended particle motion and use this to simulate the cell motion and distribution in the NASA bioreactor. We present the modelling framework in detail as well as discuss the most salient simulated results. The nutrient distribution in the bioreactor is not discussed in this paper. We expect that these results would help optimise the culture conditions for the cells in the rotating bioreactors.
Last update: 9 September 2013