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Processes 2014, 2(1), 167-179; doi:10.3390/pr2010167
Article

Towards a Tissue-Engineered Ligament: Design and Preliminary Evaluation of a Dedicated Multi-Chamber Tension-Torsion Bioreactor

1,†,* , 2,†
, 3
, 3
, 4
, 1
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 and 5
1 CNRS, LEMTA, UMR 7563, Université de Lorraine, 2 Avenue de la Forêt de Haye, 54504 Vandeuvre-lès-Nancy, France 2 Institute of Health and Biomedical Innovation, Queensland University of Technology, Cnr Blamey Street & Musk Avenue, Kelvin Grove Brisbane, Queensland 4059, Australia 3 CNRS, LRGP, UMR 7274, Université de Lorraine, 2 Avenue de la Forêt de Haye, 54504 Vandeuvre-lès-Nancy, France 4 Department of Electromechanical Engineering, School of Mechanical Engineering, Yangtze University, 1 Xueyuan Road, Jingzhou 434023, China 5 CNRS, IMoPA, UMR 7365, Biopôle, Université de Lorraine, 9 Avenue de la Forêt de Haye, 54504 Vandeuvre-lès-Nancy, France 6 PTIBC-IBISA, CNRS, FR3209, Biopôle, Université de Lorraine, 9 Avenue de la Forêt de Haye, 54504 Vandeuvre-lès-Nancy, France These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 3 January 2014 / Revised: 7 February 2014 / Accepted: 10 February 2014 / Published: 19 February 2014
(This article belongs to the Special Issue Design of Bioreactor Systems for Tissue Engineering)
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Abstract

Tissue engineering may constitute a promising alternative to current strategies in ligament repair, providing that suitable scaffolds and culture conditions are proposed. The objective of the present contribution is to present the design and instrumentation of a novel multi-chamber tension-torsion bioreactor dedicated to ligament tissue engineering. A preliminary biological evaluation of a new braided scaffold within this bioreactor under dynamic loading is reported, starting with the development of a dedicated seeding protocol validated from static cultures. The results of these preliminary biological characterizations confirm that the present combination of scaffold, seeding protocol and bioreactor may enable us to head towards a suitable ligament tissue-engineered construct.
Keywords: bioreactor; braided scaffold; stem cells; ligament tissue engineering bioreactor; braided scaffold; stem cells; ligament tissue engineering
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Laurent, C.P.; Vaquette, C.; Martin, C.; Guedon, E.; Wu, X.; Delconte, A.; Dumas, D.; Hupont, S.; Isla, N.D.; Rahouadj, R.; Wang, X. Towards a Tissue-Engineered Ligament: Design and Preliminary Evaluation of a Dedicated Multi-Chamber Tension-Torsion Bioreactor. Processes 2014, 2, 167-179.

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