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Processes 2014, 2(1), 167-179; doi:10.3390/pr2010167
Article

Towards a Tissue-Engineered Ligament: Design and Preliminary Evaluation of a Dedicated Multi-Chamber Tension-Torsion Bioreactor

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Received: 3 January 2014; in revised form: 7 February 2014 / Accepted: 10 February 2014 / Published: 19 February 2014
(This article belongs to the Special Issue Design of Bioreactor Systems for Tissue Engineering)
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Abstract: Tissue engineering may constitute a promising alternative to current strategies in ligament repair, providing that suitable scaffolds and culture conditions are proposed. The objective of the present contribution is to present the design and instrumentation of a novel multi-chamber tension-torsion bioreactor dedicated to ligament tissue engineering. A preliminary biological evaluation of a new braided scaffold within this bioreactor under dynamic loading is reported, starting with the development of a dedicated seeding protocol validated from static cultures. The results of these preliminary biological characterizations confirm that the present combination of scaffold, seeding protocol and bioreactor may enable us to head towards a suitable ligament tissue-engineered construct.
Keywords: bioreactor; braided scaffold; stem cells; ligament tissue engineering bioreactor; braided scaffold; stem cells; ligament tissue engineering
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Laurent, C.P.; Vaquette, C.; Martin, C.; Guedon, E.; Wu, X.; Delconte, A.; Dumas, D.; Hupont, S.; Isla, N.D.; Rahouadj, R.; Wang, X. Towards a Tissue-Engineered Ligament: Design and Preliminary Evaluation of a Dedicated Multi-Chamber Tension-Torsion Bioreactor. Processes 2014, 2, 167-179.

AMA Style

Laurent CP, Vaquette C, Martin C, Guedon E, Wu X, Delconte A, Dumas D, Hupont S, Isla ND, Rahouadj R, Wang X. Towards a Tissue-Engineered Ligament: Design and Preliminary Evaluation of a Dedicated Multi-Chamber Tension-Torsion Bioreactor. Processes. 2014; 2(1):167-179.

Chicago/Turabian Style

Laurent, Cédric P.; Vaquette, Cédryck; Martin, Céline; Guedon, Emmanuel; Wu, Xiude; Delconte, Alain; Dumas, Dominique; Hupont, Sébastien; Isla, Natalia D.; Rahouadj, Rachid; Wang, Xiong. 2014. "Towards a Tissue-Engineered Ligament: Design and Preliminary Evaluation of a Dedicated Multi-Chamber Tension-Torsion Bioreactor." Processes 2, no. 1: 167-179.

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