Special Issue "Radical Chemistry"
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: closed (31 August 2011)
Prof. Dr. Rebecca Braslau
Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA
Interests: synthetic organic chemistry; organic free radicals; nitroxides; nitroxide-mediated free radical polymerization; development of tailored materials for applications in nanotechnology; nitroxide-based sensors
The use of free radical intermediates in applications ranging from synthetic methodology, controlled polymerization, biomedical probes and applications in nanotechnology has flourished, growing upon the well-grounded foundation of physical measurements pioneered during the previous century. The famed “high reactivity” of most free radical intermediates has opened doors to reactions under very mild conditions, while the “lack of selectivity” often associated with free radical species can either be circumvented by astute choreography of reaction conditions, on in some cases is simply not true: some free radical reactions are exquisitely selective. For example, carbon free radical intermediates are often highly chemoselective, adding to activated olefins while remaining inert to protic alcohol, amine and carboxylic acid functionalities as well as polar groups such as carbonyls. This allows many radical reactions to be carried out without the necessity for protecting groups required under ionic reaction conditions. The chain nature of the majority of free radical processes provides an extremely efficient vehicle for transformations that evoke the elegance of catalytic processes. The use of paramagnetic persistent radicals, such as nitroxides, provides sensitive tools for probing dynamic systems using EPR, the opportunity to design new materials, and an entry to novel sensors. This is an exciting time in the field of free radical chemistry. It is my hope that this Special Edition on Free Radicals will present a forum that will reflect the creativity and diversity of advances in free radical chemistry 110 years after Moses Gomberg first demonstrated the existence of a free radical species.
Dr. Rebecca Braslau
- chain reaction
- radical cascade
- electron transfer
- radical living polymerization
- persistent radical