Special Issue "Radical Chemistry"


A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: closed (31 August 2011)

Special Issue Editor

Guest Editor
Prof. Dr. Rebecca Braslau
Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA
Website: http://chemistry.ucsc.edu/faculty/braslau.html
E-Mail: braslau@chemistry.ucsc.edu
Interests: synthetic organic chemistry; organic free radicals; nitroxides; nitroxide-mediated free radical polymerization; development of tailored materials for applications in nanotechnology; nitroxide-based sensors

Special Issue Information

Dear Colleagues,

The use of free radical intermediates in applications ranging from synthetic methodology, controlled polymerization, biomedical probes and applications in nanotechnology has flourished, growing upon the well-grounded foundation of physical measurements pioneered during the previous century.  The famed “high reactivity” of most free radical intermediates has opened doors to reactions under very mild conditions, while the “lack of selectivity” often associated with free radical species can either be circumvented by astute choreography of reaction conditions, on in some cases is simply not true: some free radical reactions are exquisitely selective. For example, carbon free radical intermediates are often highly chemoselective, adding to activated olefins while remaining inert to protic alcohol, amine and carboxylic acid functionalities as well as polar groups such as carbonyls. This allows many radical reactions to be carried out without the necessity for protecting groups required under ionic reaction conditions. The chain nature of the majority of free radical processes provides an extremely efficient vehicle for transformations that evoke the elegance of catalytic processes.  The use of paramagnetic persistent radicals, such as nitroxides, provides sensitive tools for probing dynamic systems using EPR, the opportunity to design new materials, and an entry to novel sensors.  This is an exciting time in the field of free radical chemistry.  It is my hope that this Special Edition on Free Radicals will present a forum that will reflect the creativity and diversity of advances in free radical chemistry 110 years after Moses Gomberg first demonstrated the existence of a free radical species.

Dr. Rebecca Braslau
Guest Editor


  • chain reaction
  • photochemistry
  • rearrangement
  • cyclization
  • fragmentation
  • radical cascade
  • electron transfer
  • antioxidant
  • radical living polymerization
  • persistent radical

Published Papers (6 papers)

Molecules 2011, 16(11), 9562-9581; doi:10.3390/molecules16119562
Received: 27 September 2011; in revised form: 7 November 2011 / Accepted: 9 November 2011 / Published: 16 November 2011
Show/Hide Abstract | Download PDF Full-text (434 KB) |  Supplementary Files

Molecules 2011, 16(10), 8428-8436; doi:10.3390/molecules16108428
Received: 25 July 2011; in revised form: 14 September 2011 / Accepted: 21 September 2011 / Published: 10 October 2011
Show/Hide Abstract | Download PDF Full-text (265 KB)
abstract graphic

Molecules 2011, 16(9), 7401-7414; doi:10.3390/molecules16097401
Received: 9 August 2011; in revised form: 25 August 2011 / Accepted: 26 August 2011 / Published: 30 August 2011
Show/Hide Abstract | Download PDF Full-text (503 KB)

Molecules 2011, 16(8), 6165-6178; doi:10.3390/molecules16086165
Received: 10 June 2011; in revised form: 15 July 2011 / Accepted: 19 July 2011 / Published: 25 July 2011
Show/Hide Abstract | Download PDF Full-text (651 KB)

Molecules 2011, 16(6), 4740-4747; doi:10.3390/molecules16064740
Received: 19 April 2011; in revised form: 27 May 2011 / Accepted: 2 June 2011 / Published: 7 June 2011
Show/Hide Abstract | Download PDF Full-text (168 KB)

Molecules 2010, 15(11), 7547-7557; doi:10.3390/molecules15117547
Received: 6 October 2010; in revised form: 19 October 2010 / Accepted: 25 October 2010 / Published: 27 October 2010
Show/Hide Abstract | Download PDF Full-text (318 KB)

Last update: 4 March 2014

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