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Molecules 2011, 16(6), 4740-4747; doi:10.3390/molecules16064740
Article

Synthesis of Gentiooligosaccharides of Genistein and Glycitein and Their Radical Scavenging and Anti-Allergic Activity

1,* , 1, 2 and 3,*
Received: 19 April 2011; in revised form: 27 May 2011 / Accepted: 2 June 2011 / Published: 7 June 2011
(This article belongs to the Special Issue Radical Chemistry)
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Abstract: The synthesis of gentiooligosaccharides of genistein and glycitein using cultured cells of Eucalyptus perriniana as biocatalysts was investigated. The cells of E. perriniana glycosylated genistein and glycitein to give the corresponding 4'-O-b-glucosides, 7-O-b-glucosides, and 7-O-b-gentiobiosides, which were two new compounds. The b-glucosides of genistein and glycitein showed 2,2-diphenyl-1-picrylhydrazyl (DPPH) free-radical scavenging activity and superoxide-radical scavenging activity. On the other hand, 7-O-b-glucosides of genistein and glycitein and the 7-O-b-gentiobioside of glycitein exerted inhibitory effects on IgE antibody production.
Keywords: gentiooligosaccharide; genistein; glycitein; DPPH free-radical scavenging activity; superoxide-radical scavenging activity; anti-allergic activity gentiooligosaccharide; genistein; glycitein; DPPH free-radical scavenging activity; superoxide-radical scavenging activity; anti-allergic activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Shimoda, K.; Kubota, N.; Hamada, H.; Hamada, H. Synthesis of Gentiooligosaccharides of Genistein and Glycitein and Their Radical Scavenging and Anti-Allergic Activity. Molecules 2011, 16, 4740-4747.

AMA Style

Shimoda K, Kubota N, Hamada H, Hamada H. Synthesis of Gentiooligosaccharides of Genistein and Glycitein and Their Radical Scavenging and Anti-Allergic Activity. Molecules. 2011; 16(6):4740-4747.

Chicago/Turabian Style

Shimoda, Kei; Kubota, Naoji; Hamada, Hatsuyuki; Hamada, Hiroki. 2011. "Synthesis of Gentiooligosaccharides of Genistein and Glycitein and Their Radical Scavenging and Anti-Allergic Activity." Molecules 16, no. 6: 4740-4747.


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