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Molecules 2011, 16(10), 8428-8436; doi:10.3390/molecules16108428
Article

Simplified Synthesis of Isotopically Labeled 5,5-Dimethyl-pyrroline N-Oxide

1,* , 1, 2 and 1
1 Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA 2 Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA
* Author to whom correspondence should be addressed.
Received: 25 July 2011 / Revised: 14 September 2011 / Accepted: 21 September 2011 / Published: 10 October 2011
(This article belongs to the Special Issue Radical Chemistry)
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Abstract

5,5-Dimethylpyrroline N-oxide (15N) and 5,5-di(trideuteromethyl)pyrroline N-oxide were synthesized from the respective isotopically labeled 2-nitropropane analogs obtained from the reaction of sodium nitrate with 2-halopropanes. This facile, straightforward process allows synthesizing isotopically labeled DMPO analogs in a 4-step reaction without special equipment.
Keywords: spin trap; isotopic labeling; DMPO spin trap; isotopic labeling; DMPO
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Leinisch, F.; Jiang, J.; Deterding, L.J.; Mason, R.P. Simplified Synthesis of Isotopically Labeled 5,5-Dimethyl-pyrroline N-Oxide. Molecules 2011, 16, 8428-8436.

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