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Molecules 2011, 16(10), 8428-8436; doi:10.3390/molecules16108428
Article

Simplified Synthesis of Isotopically Labeled 5,5-Dimethyl-pyrroline N-Oxide

1,* , 1, 2 and 1
Received: 25 July 2011 / Revised: 14 September 2011 / Accepted: 21 September 2011 / Published: 10 October 2011
(This article belongs to the Special Issue Radical Chemistry)
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Abstract

5,5-Dimethylpyrroline N-oxide (15N) and 5,5-di(trideuteromethyl)pyrroline N-oxide were synthesized from the respective isotopically labeled 2-nitropropane analogs obtained from the reaction of sodium nitrate with 2-halopropanes. This facile, straightforward process allows synthesizing isotopically labeled DMPO analogs in a 4-step reaction without special equipment.
Keywords: spin trap; isotopic labeling; DMPO spin trap; isotopic labeling; DMPO
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Leinisch, F.; Jiang, J.; Deterding, L.J.; Mason, R.P. Simplified Synthesis of Isotopically Labeled 5,5-Dimethyl-pyrroline N-Oxide. Molecules 2011, 16, 8428-8436.

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