Next Article in Journal
In Vitro Anti-HMPV Activity of Meroditerpenoids from Marine Alga Stypopodium zonale (Dictyotales)
Next Article in Special Issue
Mn(III)-Initiated Facile Oxygenation of Heterocyclic 1,3-Dicarbonyl Compounds
Previous Article in Journal
Direct Purification of Pectinase from Mango (Mangifera Indica Cv. Chokanan) Peel Using a PEG/Salt-Based Aqueous Two Phase System
Previous Article in Special Issue
Antioxidant Capacity of Ocimum basilicum L. and Origanum vulgare L. Extracts
Article Menu

Article Versions

Export Article

Open AccessArticle
Molecules 2011, 16(10), 8428-8436; doi:10.3390/molecules16108428

Simplified Synthesis of Isotopically Labeled 5,5-Dimethyl-pyrroline N-Oxide

1
Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA
2
Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA
*
Author to whom correspondence should be addressed.
Received: 25 July 2011 / Revised: 14 September 2011 / Accepted: 21 September 2011 / Published: 10 October 2011
(This article belongs to the Special Issue Radical Chemistry)
Download PDF [265 KB, uploaded 18 June 2014]   |  

Abstract

5,5-Dimethylpyrroline N-oxide (15N) and 5,5-di(trideuteromethyl)pyrroline N-oxide were synthesized from the respective isotopically labeled 2-nitropropane analogs obtained from the reaction of sodium nitrate with 2-halopropanes. This facile, straightforward process allows synthesizing isotopically labeled DMPO analogs in a 4-step reaction without special equipment.
Keywords: spin trap; isotopic labeling; DMPO spin trap; isotopic labeling; DMPO
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Leinisch, F.; Jiang, J.; Deterding, L.J.; Mason, R.P. Simplified Synthesis of Isotopically Labeled 5,5-Dimethyl-pyrroline N-Oxide. Molecules 2011, 16, 8428-8436.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top