Special Issue "Developments in Fragment-Based Lead Discovery"
Deadline for manuscript submissions: closed (28 February 2016)
Fragment-based lead discovery (FBLD), also known as fragment-based drug discovery (FBDD), is a powerful method to identify drug leads. While typical high throughput screening relies on libraries containing a million or more drug-sized molecules, fragment-based screening relies on smaller libraries of perhaps a few thousand small molecular fragments, each only half the size of a typical drug molecule, generally less than 300 Daltons. Because fragments are small, the techniques to find and validate them must be sensitive, specific, and, often, specialized. Moreover, it can be difficult to improve the potency of a fragment from a millimolar hit to a nanomolar drug lead. Despite these challenges, FBLD has become widely embraced by the pharmaceutical and biotech industries, as well as academia. A technical symposium on the development of FBLD was organized during the 2015 International Chemical Congress of Pacific Basin Societies (Pacifichem 2015), including all aspects of FBLD, from library design and the various biophysical, biochemical, and computational fragment-identification methods, through fragment-to-lead campaigns, and finally, lead optimization and success stories. Original high-quality papers related to these themes are especially solicited in this Special Issue.
Prof. Raymond S. Norton
Dr. Martin Scanlon
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.
- Library design
- Biophysical methods to assess binding
- Structure characterization
- Fragment elaboration