Special Issue "Dendrimers in Medicine and Biotechnology"
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: 15 July 2014
Prof. Dr. Zofia Urbanczyk-Lipkowska
Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka Str. 44/52, 01-224 Warsaw, Poland
Interests: dendrimer chemistry; solid phase structural studies of branched molecules; photochromic compounds; chiral coordination polymers
During last 20 years of dendrimers history – these eye-catching polymeric molecules generated non-precedented interest in many areas, including biomedical and pharmaceutical research. Only this year over 70 review articles on dendrimers synthesis, structure and various properties and applications have been published. Due to polyvalency, capability to control chemistry and properties of the surface area and molecular interior, dendrimers exhibit valuable properties of nanoscale delivery systems, bioconjugates for in-vitro immunoassays for antigens, and materials for vaccination. Their potential in treatment of lifestyle and civilization diseases such as cancer, diabetes, viral and microbial infections, Alzheimer and prion-associated diseases, etc. has also been recognized. Bioactivity of the designed dendrimers suggests them as promising therapeutic agents in contemporary regenerative medicine, involved in wound healing, tissue and cartilage reconstruction as well as bone mineralization. The potential applications of de novo – designed dendrimers in such areas as boron neutron capture therapy, as MRI contrast reagents, and materials for enhanced transfection cannot be overlooked. First applications of dendrimers for topical treatments against herpes simplex virus or for prevention of HIV transmission will be available soon.
This special issue of Molecules “Dendrimers in Medicine and Biotechnology” welcomes previously unpublished manuscripts covering aspects of new synthetic and characterization methods of dendrimers, new molecular entities, their therapeutic potential in the area of medicine and biotechnology.
Prof. Zofia Urbanczyk-Lipkowska
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.
- regenerative medicine
Review: The Janus Face of PAMAM Dendrimers Used to Potentially Cure Nonenzymatic Modifications of Biomacromolecules in Metabolic Disorders—A Critical Review of the Pros and Cons
Molecules 2013, 18(11), 13769-13811; doi:10.3390/molecules181113769
Received: 1 July 2013; in revised form: 30 October 2013 / Accepted: 31 October 2013 / Published: 7 November 2013| Download PDF Full-text (6376 KB)
Article: Intracellular Environment-Responsive Stabilization of Polymer Vesicles Formed from Head-Tail Type Polycations Composed of a Polyamidoamine Dendron and Poly(L-lysine)
Molecules 2013, 18(10), 12168-12179; doi:10.3390/molecules181012168
Received: 6 August 2013; in revised form: 18 September 2013 / Accepted: 23 September 2013 / Published: 30 September 2013| Download PDF Full-text (1165 KB)
Article: Analysis of Biotinylated Generation 4 Poly(amidoamine) (PAMAM) Dendrimer Distribution in the Rat Brain and Toxicity in a Cellular Model of the Blood-Brain Barrier
Molecules 2013, 18(9), 11537-11552; doi:10.3390/molecules180911537
Received: 23 July 2013; in revised form: 3 September 2013 / Accepted: 10 September 2013 / Published: 17 September 2013| Download PDF Full-text (3257 KB)
Article: DNA Condensation by Partially Acetylated Poly(amido amine) Dendrimers: Effects of Dendrimer Charge Density on Complex Formation
Molecules 2013, 18(9), 10707-10720; doi:10.3390/molecules180910707
Received: 1 August 2013; in revised form: 29 August 2013 / Accepted: 30 August 2013 / Published: 3 September 2013| Download PDF Full-text (1153 KB)
Article: An Azabisphosphonate-Capped Poly(phosphorhydrazone) Dendrimer for the Treatment of Endotoxin-Induced Uveitis
Molecules 2013, 18(8), 9305-9316; doi:10.3390/molecules18089305
Received: 15 July 2013; in revised form: 26 July 2013 / Accepted: 1 August 2013 / Published: 5 August 2013| Download PDF Full-text (871 KB)
Article: The Effect of PAMAM Dendrimers on the Antibacterial Activity of Antibiotics with Different Water Solubility
Molecules 2013, 18(7), 8607-8617; doi:10.3390/molecules18078607
Received: 20 June 2013; in revised form: 12 July 2013 / Accepted: 16 July 2013 / Published: 22 July 2013| Download PDF Full-text (226 KB)
Molecules 2013, 18(7), 8440-8460; doi:10.3390/molecules18078440
Received: 27 June 2013; in revised form: 8 July 2013 / Accepted: 15 July 2013 / Published: 17 July 2013| Download PDF Full-text (587 KB)
Molecules 2013, 18(7), 7912-7929; doi:10.3390/molecules18077912
Received: 18 June 2013; in revised form: 25 June 2013 / Accepted: 26 June 2013 / Published: 5 July 2013| Download PDF Full-text (458 KB)
Article: Novel Antimicrobial Peptide Dendrimers with Amphiphilic Surface and Their Interactions with Phospholipids — Insights from Mass Spectrometry
Molecules 2013, 18(6), 7120-7144; doi:10.3390/molecules18067120
Received: 9 April 2013; in revised form: 4 June 2013 / Accepted: 6 June 2013 / Published: 18 June 2013| Download PDF Full-text (977 KB) | Supplementary Files
Article: Vortex-Induced Alignment of a Water Soluble Supramolecular Nanofiber Composed of an Amphiphilic Dendrimer
Molecules 2013, 18(6), 7071-7080; doi:10.3390/molecules18067071
Received: 14 May 2013; in revised form: 7 June 2013 / Accepted: 8 June 2013 / Published: 17 June 2013| Download PDF Full-text (511 KB) | Supplementary Files
Molecules 2013, 18(4), 4451-4466; doi:10.3390/molecules18044451
Received: 18 March 2013; in revised form: 3 April 2013 / Accepted: 11 April 2013 / Published: 15 April 2013| Download PDF Full-text (545 KB)
Last update: 1 November 2013