Molecules 2013, 18(7), 8607-8617; doi:10.3390/molecules18078607
Article

The Effect of PAMAM Dendrimers on the Antibacterial Activity of Antibiotics with Different Water Solubility

1,* email, 1,†email, 2,†email, 2email and 2email
Received: 20 June 2013; in revised form: 12 July 2013 / Accepted: 16 July 2013 / Published: 22 July 2013
(This article belongs to the Special Issue Dendrimers in Medicine and Biotechnology)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Erythromycin (EM) and tobramycin (TOB) are well-known and widely used antibiotics, belonging to different therapeutic groups: macrolide and aminoglycoside, respectively. Moreover, they possess different solubility: EM is slightly soluble and TOB is freely soluble in water. It was previously demonstrated that PAMAM dendrimers enhanced the pharmacological activity of antifungal drugs by increasing their solubility. Therefore, it appears interesting to investigate the effect of PAMAM-NH2 and PAMAM-OH dendrimers generation 2 (G2) and generation 3 (G3) on the antibacterial activity of antibiotics with different water solubility. In this study it was shown that the aqueous solubility of EM was significantly increased by PAMAM dendrimers (PAMAM-NH2 and PAMAM-OH caused about 8- and 7- fold solubility increases, respectively). However, it was indicated that despite the increase in the solubility, there was only slight influence on the antibacterial activity of EM (2- and 4- fold decreases in the MBC values of EM in the presence of PAMAM-OH G3 and PAMAM-NH2 G2 or G3 for strains of Staphylococcus aureus were noted, respectively). It was also found that there was no influence of PAMAM on the antibacterial activity of hydrophilic TOB.
Keywords: PAMAM dendrimer; tobramycin; erythromycin; antibacterial activity; water solubility
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MDPI and ACS Style

Winnicka, K.; Wroblewska, M.; Wieczorek, P.; Sacha, P.T.; Tryniszewska, E.A. The Effect of PAMAM Dendrimers on the Antibacterial Activity of Antibiotics with Different Water Solubility. Molecules 2013, 18, 8607-8617.

AMA Style

Winnicka K, Wroblewska M, Wieczorek P, Sacha PT, Tryniszewska EA. The Effect of PAMAM Dendrimers on the Antibacterial Activity of Antibiotics with Different Water Solubility. Molecules. 2013; 18(7):8607-8617.

Chicago/Turabian Style

Winnicka, Katarzyna; Wroblewska, Magdalena; Wieczorek, Piotr; Sacha, Pawel T.; Tryniszewska, Elzbieta A. 2013. "The Effect of PAMAM Dendrimers on the Antibacterial Activity of Antibiotics with Different Water Solubility." Molecules 18, no. 7: 8607-8617.


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