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Molecules 2013, 18(12), 14519-14528; doi:10.3390/molecules181214519
Article

Ultrasound-Promoted One-Pot, Four-Component Synthesis of Pyridin-2(1H)-One Derivatives

1,2,†, 3,†, 2, 2, 4,* , 4, 2 and 2,*
Received: 30 September 2013 / Revised: 19 November 2013 / Accepted: 19 November 2013 / Published: 25 November 2013
(This article belongs to the Special Issue Combinatorial Synthesis)
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Abstract

An efficient one-pot synthesis of 1,6-diamino-2-oxo-1,2,3,4-tetrahydro- pyridine-3,5-dicarbonitrile derivatives by four-component piperidine-catalyzed reactions of a ketone, malononitrile, ethyl cyanoacetate and hydrazine hydrate under ultrasound irradiation is described. This method provides several advantages such as shorter reaction times, excellent yields, and a simple workup procedure.
Keywords: pyridin-2(1H)-one; ultrasound irradiation; multicomponent reaction pyridin-2(1H)-one; ultrasound irradiation; multicomponent reaction
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Yang, J.; Li, Q.; Zhang, J.; Lin, W.; Wang, J.; Wang, Y.; Huang, Z.; Shi, D. Ultrasound-Promoted One-Pot, Four-Component Synthesis of Pyridin-2(1H)-One Derivatives. Molecules 2013, 18, 14519-14528.

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