Next Article in Journal
Perfluoroalkanesulfonamide Organocatalysts for Asymmetric Conjugate Additions of Branched Aldehydes to Vinyl Sulfones
Next Article in Special Issue
Mixture-Based Combinatorial Libraries from Small Individual Peptide Libraries: A Case Study on α1-Antitrypsin Deficiency
Previous Article in Journal
Facile Creation of 3-Substituted-3-Hydroxy-2-Oxindoles by Arginine-Catalyzed Aldol Reactions of α,β-Unsaturated Ketones with Isatins
Previous Article in Special Issue
Combinatorial Techniques to Efficiently Investigate and Optimize Organic Thin Film Processing and Properties
Molecules 2013, 18(12), 14519-14528; doi:10.3390/molecules181214519
Article

Ultrasound-Promoted One-Pot, Four-Component Synthesis of Pyridin-2(1H)-One Derivatives

1,2,†, 3,†, 2, 2, 4,* , 4, 2 and 2,*
Received: 30 September 2013; in revised form: 19 November 2013 / Accepted: 19 November 2013 / Published: 25 November 2013
(This article belongs to the Special Issue Combinatorial Synthesis)
Download PDF [365 KB, uploaded 18 June 2014]
Abstract: An efficient one-pot synthesis of 1,6-diamino-2-oxo-1,2,3,4-tetrahydro- pyridine-3,5-dicarbonitrile derivatives by four-component piperidine-catalyzed reactions of a ketone, malononitrile, ethyl cyanoacetate and hydrazine hydrate under ultrasound irradiation is described. This method provides several advantages such as shorter reaction times, excellent yields, and a simple workup procedure.
Keywords: pyridin-2(1H)-one; ultrasound irradiation; multicomponent reaction pyridin-2(1H)-one; ultrasound irradiation; multicomponent reaction
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Yang, J.; Li, Q.; Zhang, J.; Lin, W.; Wang, J.; Wang, Y.; Huang, Z.; Shi, D. Ultrasound-Promoted One-Pot, Four-Component Synthesis of Pyridin-2(1H)-One Derivatives. Molecules 2013, 18, 14519-14528.

AMA Style

Yang J, Li Q, Zhang J, Lin W, Wang J, Wang Y, Huang Z, Shi D. Ultrasound-Promoted One-Pot, Four-Component Synthesis of Pyridin-2(1H)-One Derivatives. Molecules. 2013; 18(12):14519-14528.

Chicago/Turabian Style

Yang, Jinming; Li, Qiang; Zhang, Juanjuan; Lin, Wei; Wang, Juxian; Wang, Yucheng; Huang, Zhibin; Shi, Daqing. 2013. "Ultrasound-Promoted One-Pot, Four-Component Synthesis of Pyridin-2(1H)-One Derivatives." Molecules 18, no. 12: 14519-14528.


Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert