Molecules 2013, 18(12), 14519-14528; doi:10.3390/molecules181214519

Ultrasound-Promoted One-Pot, Four-Component Synthesis of Pyridin-2(1H)-One Derivatives

1 School of Pharmacy, Yancheng Teachers University, Yancheng 224051, Jiangsu, China 2 Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, Jiangsu, China 3 Hainan Chuntch Pharmaceutical Company Limited, Haikou 570216, Hainan, China 4 Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Perkin Union, Medical College, Beijing 100050, China These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 30 September 2013; in revised form: 19 November 2013 / Accepted: 19 November 2013 / Published: 25 November 2013
(This article belongs to the Special Issue Combinatorial Synthesis)
PDF Full-text Download PDF Full-Text [365 KB, uploaded 25 November 2013 12:15 CET]
Abstract: An efficient one-pot synthesis of 1,6-diamino-2-oxo-1,2,3,4-tetrahydro- pyridine-3,5-dicarbonitrile derivatives by four-component piperidine-catalyzed reactions of a ketone, malononitrile, ethyl cyanoacetate and hydrazine hydrate under ultrasound irradiation is described. This method provides several advantages such as shorter reaction times, excellent yields, and a simple workup procedure.
Keywords: pyridin-2(1H)-one; ultrasound irradiation; multicomponent reaction

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Yang, J.; Li, Q.; Zhang, J.; Lin, W.; Wang, J.; Wang, Y.; Huang, Z.; Shi, D. Ultrasound-Promoted One-Pot, Four-Component Synthesis of Pyridin-2(1H)-One Derivatives. Molecules 2013, 18, 14519-14528.

AMA Style

Yang J, Li Q, Zhang J, Lin W, Wang J, Wang Y, Huang Z, Shi D. Ultrasound-Promoted One-Pot, Four-Component Synthesis of Pyridin-2(1H)-One Derivatives. Molecules. 2013; 18(12):14519-14528.

Chicago/Turabian Style

Yang, Jinming; Li, Qiang; Zhang, Juanjuan; Lin, Wei; Wang, Juxian; Wang, Yucheng; Huang, Zhibin; Shi, Daqing. 2013. "Ultrasound-Promoted One-Pot, Four-Component Synthesis of Pyridin-2(1H)-One Derivatives." Molecules 18, no. 12: 14519-14528.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert