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Ultrasound-Promoted One-Pot, Four-Component Synthesis of Pyridin-2(1H)-One Derivatives
School of Pharmacy, Yancheng Teachers University, Yancheng 224051, Jiangsu, China
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, Jiangsu, China
Hainan Chuntch Pharmaceutical Company Limited, Haikou 570216, Hainan, China
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Perkin Union, Medical College, Beijing 100050, China
These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 30 September 2013; in revised form: 19 November 2013 / Accepted: 19 November 2013 / Published: 25 November 2013
Abstract: An efficient one-pot synthesis of 1,6-diamino-2-oxo-1,2,3,4-tetrahydro- pyridine-3,5-dicarbonitrile derivatives by four-component piperidine-catalyzed reactions of a ketone, malononitrile, ethyl cyanoacetate and hydrazine hydrate under ultrasound irradiation is described. This method provides several advantages such as shorter reaction times, excellent yields, and a simple workup procedure.
Keywords: pyridin-2(1H)-one; ultrasound irradiation; multicomponent reaction
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Yang, J.; Li, Q.; Zhang, J.; Lin, W.; Wang, J.; Wang, Y.; Huang, Z.; Shi, D. Ultrasound-Promoted One-Pot, Four-Component Synthesis of Pyridin-2(1H)-One Derivatives. Molecules 2013, 18, 14519-14528.
Yang J, Li Q, Zhang J, Lin W, Wang J, Wang Y, Huang Z, Shi D. Ultrasound-Promoted One-Pot, Four-Component Synthesis of Pyridin-2(1H)-One Derivatives. Molecules. 2013; 18(12):14519-14528.
Yang, Jinming; Li, Qiang; Zhang, Juanjuan; Lin, Wei; Wang, Juxian; Wang, Yucheng; Huang, Zhibin; Shi, Daqing. 2013. "Ultrasound-Promoted One-Pot, Four-Component Synthesis of Pyridin-2(1H)-One Derivatives." Molecules 18, no. 12: 14519-14528.