Special Issue "Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry"

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A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: closed (30 April 2013)

Special Issue Editor

Guest Editor
Prof. Dr. Arduino A. Mangoni
Division of Applied Medicine, Section of Translational Medical Sciences, School of Medicine & Dentistry, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
Website: http://www.abdn.ac.uk/medicine-dentistry/staff/details/a.a.mangoni
E-Mail: a.a.mangoni@abdn.ac.uk
Phone: +44 (0)1224 437841
Fax: +44(0) 1224 555766
Interests: vascular pharmacology; geriatric clinical pharmacology; pharmacoepidemiology and safety of non-steroidal anti-inflammatory; antimuscarinic drugs in older patients

Special Issue Information

Dear Colleagues,

Although anti-inflammatory agents are extensively prescribed across all age groups worldwide there are several unanswered questions about their exact mechanism of action and their potential renal and cardiovascular toxicity. These issues are largely related to 1) the validity of available methods for assessing selectivity towards the cyclooxygenase enzyme isoforms COX-1 and COX-2; 2) the exact role played by COX-1 and COX-2 in renal and vascular homeostasis in animal models and humans; and 3) the interpretation of data from pharmacoepidemiological studies and meta-analyses.
This special issue of Molecules welcomes previously unpublished manuscripts covering all aspects of pharmacology and chemistry of anti-inflammatory drugs, in particular the development of novel anti-inflammatory drugs and methods for assessing COX selectivity, pharmacodynamic effects of novel and existing anti-inflammatory drugs in animal models and humans, and the expression and role of different COX isoforms in the kidney and vasculature.

Prof. Dr. Arduino A Mangoni
Guest Editor

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs).

Keywords

  • organic chemistry
  • drug development
  • enzyme kinetics
  • enzyme expression
  • pharmacokinetics
  • pharmacodynamics
  • cyclooxygenase
  • safety
  • renal toxicity
  • cardiovascular toxicity
  • inflammation
  • pain
  • medicinal chemistry

Published Papers (9 papers)

Molecules 2013, 18(9), 10953-10972; doi:10.3390/molecules180910953
Received: 17 June 2013; in revised form: 26 August 2013 / Accepted: 27 August 2013 / Published: 5 September 2013
Show/Hide Abstract | Download PDF Full-text (218 KB)

Molecules 2013, 18(9), 10132-10145; doi:10.3390/molecules180910132
Received: 4 July 2013; in revised form: 14 August 2013 / Accepted: 15 August 2013 / Published: 22 August 2013
Show/Hide Abstract | Download PDF Full-text (897 KB)

Molecules 2013, 18(7), 8083-8094; doi:10.3390/molecules18078083
Received: 2 May 2013; in revised form: 3 July 2013 / Accepted: 4 July 2013 / Published: 9 July 2013
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Molecules 2013, 18(6), 7253-7270; doi:10.3390/molecules18067253
Received: 27 April 2013; in revised form: 5 June 2013 / Accepted: 14 June 2013 / Published: 19 June 2013
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Molecules 2013, 18(6), 7023-7034; doi:10.3390/molecules18067023
Received: 22 April 2013; in revised form: 30 May 2013 / Accepted: 13 June 2013 / Published: 17 June 2013
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Molecules 2013, 18(6), 6584-6596; doi:10.3390/molecules18066584
Received: 18 March 2013; in revised form: 27 May 2013 / Accepted: 31 May 2013 / Published: 4 June 2013
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Molecules 2013, 18(5), 6113-6127; doi:10.3390/molecules18056113
Received: 11 March 2013; in revised form: 7 May 2013 / Accepted: 10 May 2013 / Published: 22 May 2013
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Molecules 2013, 18(3), 3595-3614; doi:10.3390/molecules18033595
Received: 31 January 2013; in revised form: 12 February 2013 / Accepted: 10 March 2013 / Published: 21 March 2013
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Molecules 2013, 18(3), 2483-2500; doi:10.3390/molecules18032483
Received: 10 January 2013; in revised form: 4 February 2013 / Accepted: 7 February 2013 / Published: 25 February 2013
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Type of Paper: Review
Title: Vitamin D Activated Pathways in Asthma Current and Future Perspectives
Authors: Konstantinos Porpodis, Paul Zarogoulidis *, Kalliopi Domvri and Konstantinos Zarogoulidis
Affiliation: Pulmonary Department, “G. Papanikolaou” General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece
Abstract: Man can synthesize Vitamin D during the action of UV radiation upon the skin. Apart from the regulation of calcium and phosphate metabolism, another critical role for Vitamin D in immunity and respiratory health has been revealed, since vitamin D receptors have been found also in other body cells. The term vitamin D insufficiency has been used to describe low levels of serum 25-hydroxyvitamin D that may be associated with a wide range of pulmonary diseases including viral and bacterial respiratory infection, asthma, chronic obstructive pulmonary disease, and cancer. This review focuses on the established relation between Vitamin D and the development of asthma. It has been found that different gene polymorphisms of the vitamin D receptor have variable associations with asthma. Besides several studies investigated the vitamin D receptor signal pathway in vitro or in experimental animal models that showed the beneficial effect of Vitamin D in asthma. Furthermore, a sufficient range of epidemiological studies have also suggested that vitamin D insufficiency is associated with low lung function. In the future, clinical trials in different asthmatic groups such as infants, children of school age and ethnic minorities are needed to establish the role of Vitamin D supplementation to prevent or to treat asthma.

Last update: 7 December 2012

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