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Molecules 2013, 18(6), 6584-6596; doi:10.3390/molecules18066584

Indomethacin Inhibits Cancer Cell Migration via Attenuation of Cellular Calcium Mobilization

1,†, 2,3,†, 4, 5, 2, 5, 6,7,8, 6,7,8, 9, 4,*  and 2,3,6,10,*
Received: 18 March 2013 / Revised: 27 May 2013 / Accepted: 31 May 2013 / Published: 4 June 2013
(This article belongs to the Special Issue Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry)
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Non-steroidal anti-inflammatory drugs (NSAIDs) were shown to reduce the risk of colorectal cancer recurrence and are widely used to modulate inflammatory responses. Indomethacin is an NSAID. Herein, we reported that indomethacin can suppress cancer cell migration through its influence on the focal complexes formation. Furthermore, endothelial growth factor (EGF)-mediated Ca2+ influx was attenuated by indomethacin in a dose dependent manner. Our results identified a new mechanism of action for indomethacin: inhibition of calcium influx that is a key determinant of cancer cell migration.
Keywords: indomethacin; EGF; COX-2; cell migration indomethacin; EGF; COX-2; cell migration
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Guo, Y.-C.; Chang, C.-M.; Hsu, W.-L.; Chiu, S.-J.; Tsai, Y.-T.; Chou, Y.-H.; Hou, M.-F.; Wang, J.-Y.; Lee, M.-H.; Tsai, K.-L.; Chang, W.-C. Indomethacin Inhibits Cancer Cell Migration via Attenuation of Cellular Calcium Mobilization. Molecules 2013, 18, 6584-6596.

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