Next Article in Journal
Synthesis and Characterization of Rice Straw/Fe3O4 Nanocomposites by a Quick Precipitation Method
Next Article in Special Issue
A Soft Coral Natural Product, 11-Episinulariolide Acetate, Inhibits Gene Expression of Cyclooxygenase-2 and Interleukin-8 through Attenuation of Calcium Signaling
Previous Article in Journal
New Lignans from the Leaves and Stems of Kadsura philippinensis
Previous Article in Special Issue
The Ameliorative Effect of Sophoricoside on Mast Cell-Mediated Allergic Inflammation in Vivo and in Vitro
Molecules 2013, 18(6), 6584-6596; doi:10.3390/molecules18066584
Article

Indomethacin Inhibits Cancer Cell Migration via Attenuation of Cellular Calcium Mobilization

1,†, 2,3,†, 4, 5, 2, 5, 6,7,8, 6,7,8, 9, 4,*  and 2,3,6,10,*
Received: 18 March 2013 / Revised: 27 May 2013 / Accepted: 31 May 2013 / Published: 4 June 2013
(This article belongs to the Special Issue Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry)
Download PDF [2293 KB, 18 June 2014; original version 18 June 2014]

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) were shown to reduce the risk of colorectal cancer recurrence and are widely used to modulate inflammatory responses. Indomethacin is an NSAID. Herein, we reported that indomethacin can suppress cancer cell migration through its influence on the focal complexes formation. Furthermore, endothelial growth factor (EGF)-mediated Ca2+ influx was attenuated by indomethacin in a dose dependent manner. Our results identified a new mechanism of action for indomethacin: inhibition of calcium influx that is a key determinant of cancer cell migration.
Keywords: indomethacin; EGF; COX-2; cell migration indomethacin; EGF; COX-2; cell migration
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Guo, Y.-C.; Chang, C.-M.; Hsu, W.-L.; Chiu, S.-J.; Tsai, Y.-T.; Chou, Y.-H.; Hou, M.-F.; Wang, J.-Y.; Lee, M.-H.; Tsai, K.-L.; Chang, W.-C. Indomethacin Inhibits Cancer Cell Migration via Attenuation of Cellular Calcium Mobilization. Molecules 2013, 18, 6584-6596.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert