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Molecules 2013, 18(6), 6584-6596; doi:10.3390/molecules18066584
Article

Indomethacin Inhibits Cancer Cell Migration via Attenuation of Cellular Calcium Mobilization

1,†, 2,3,†, 4, 5, 2, 5, 6,7,8, 6,7,8, 9, 4,*  and 2,3,6,10,*
1 Department of Neurology, Changhua Christian Hospital, Changhua 500, Taiwan 2 Department of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan 3 Master Program for Clinical Pharmacogenomics and Pharmacoproteomics, School of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan 4 Department of Physiology, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan 5 Department of Urology, College of Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan 6 Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan 7 Division of Gastroenterologic and General Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan 8 Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan 9 Graduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan 10 Department of Pharmacy, Taipei Medical University-Wanfang Hospital, Taipei 11031, Taiwan These authors contribute equally to this paper.
* Authors to whom correspondence should be addressed.
Received: 18 March 2013 / Revised: 27 May 2013 / Accepted: 31 May 2013 / Published: 4 June 2013
(This article belongs to the Special Issue Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry)
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Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) were shown to reduce the risk of colorectal cancer recurrence and are widely used to modulate inflammatory responses. Indomethacin is an NSAID. Herein, we reported that indomethacin can suppress cancer cell migration through its influence on the focal complexes formation. Furthermore, endothelial growth factor (EGF)-mediated Ca2+ influx was attenuated by indomethacin in a dose dependent manner. Our results identified a new mechanism of action for indomethacin: inhibition of calcium influx that is a key determinant of cancer cell migration.
Keywords: indomethacin; EGF; COX-2; cell migration indomethacin; EGF; COX-2; cell migration
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Guo, Y.-C.; Chang, C.-M.; Hsu, W.-L.; Chiu, S.-J.; Tsai, Y.-T.; Chou, Y.-H.; Hou, M.-F.; Wang, J.-Y.; Lee, M.-H.; Tsai, K.-L.; Chang, W.-C. Indomethacin Inhibits Cancer Cell Migration via Attenuation of Cellular Calcium Mobilization. Molecules 2013, 18, 6584-6596.

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