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Molecules 2013, 18(5), 6113-6127; doi:10.3390/molecules18056113
Article

The Ameliorative Effect of Sophoricoside on Mast Cell-Mediated Allergic Inflammation in Vivo and in Vitro

1,†
, 2,†
, 2
, 3
, 4
, 5
, 6,†
 and 5,†,*
1 Department of Cosmeceutical Science, Daegu Hanny University, Yugok-dong, Kyungsan 712-715, Korea 2 Department of Herbal Medicinal Pharmacology, Daegu Haany University, Yugok-dong, Kyungsan 712-715, Korea 3 Department of Pharmacy, Keimyung University, Sindang-dong, Dalseo-gu, Dae-gu 704-701, Korea 4 Department of Herbal Foodceutical Science, Daegu Haany University, Yugok-dong, Kyungsan 712-715, Korea 5 College of Korean Medicine, Institute of Korean Medicine, Kyung Hee University, 1 Hoegi-Dong, Dongdaemun-gu, Seoul 130-701, Korea 6 Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Jeonbuk 570-749, Korea These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 11 March 2013 / Revised: 7 May 2013 / Accepted: 10 May 2013 / Published: 22 May 2013
(This article belongs to the Special Issue Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry)
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Abstract

Sophoricoside exhibits numerous pharmacological effects, including anti- inflammatory and anti-cancer actions, yet the exact mechanism that accounts for the anti-allergic effects of sophoricoside is not completely understood. The aim of the present study was to elucidate whether and how sophoricoside modulates the mast cell-mediated allergic inflammation in vitro and in vivo. We investigated the pharmacological effects of sophoricoside on both compound 48/80 or histamine-induced scratching behaviors and 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis in mice. Additionally, to find a possible explanation for the anti-inflammatory effects of sophoricoside, we evaluated the effects of sophoricoside on the production of histamine and inflammatory cytokines and activation of nuclear factor-κB (NF-κB) and caspase-1 in phorbol 12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated human mast cells (HMC-1). The finding of this study demonstrated that sophoricoside reduced compound 48/80 or histamine-induced scratching behaviors and DNCB-induced atopic dermatitis in mice. Additionally, sophoricoside inhibited the production of inflammatory cytokines as well as the activation of NF-κB and caspase-1 in stimulated HMC-1. Collectively, the findings of this study provide us with novel insights into the pharmacological actions of sophoricoside as a potential molecule for use in the treatment of allergic inflammation diseases.
Keywords: sophoricoside; inflammatory cytokine; mast cells; allergic inflammation sophoricoside; inflammatory cytokine; mast cells; allergic inflammation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kim, S.-J.; Lee, G.-Y.; Jung, J.-W.; Oh, S.-R.; Ahn, E.-M.; Kim, S.-H.; Hong, S.-H.; Um, J.-Y. The Ameliorative Effect of Sophoricoside on Mast Cell-Mediated Allergic Inflammation in Vivo and in Vitro. Molecules 2013, 18, 6113-6127.

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