Special Issue "Phospholipids: Structure and Function"
Deadline for manuscript submissions: closed (1 November 2017)
Prof. Mu-Ping Nieh
Chemical & Biomolecular Engineering, School of Engineering, University of Connecticut, 97 North Eagleville Road, Unit 3136, Storrs, CT-06269-3136, United States
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Interests: biomembranes; well-defined lipid nanoparticles; self-sssembly; nanostructural charatcerization (scattering); therapeutic/diagnostic nanocarriers; lipid transfer; polymer/lipid and inorganic nanoparticle/lipid interactions
Lipids are the building blocks of biological membranes, which define the boundary, control the transport, and host the functional-associated proteins of cells or organelles. Because of their amphiphilic properties and biological compatibility, lipids have also been used as delivery nanocarriers for therapeutics or diagnostics in various forms of structures, such as liposomes, solid nanoparticles, or micelles. Generally speaking, multiple lipid species are found in biomembranes or are used in the constituents of nanoparticles. The aforementioned functions and applications often depend on the structures/morphology of the associated lipid species (e.g., segregation, self-assembly and lipid/protein complex), which can be controlled by their molecular architectures (spontaneous curvature), hydrophobic–hydrophilic interactions, crystallinity of the acyl chains, charge densities, bilayer rigidity, and salinity of the solution. Therefore, the structure–function relationship is important for advancing our knowledge of related biological functions and the formation mechanism of well-defined lipid self-assembling nanoparticles. The Special Issue aims at (1) experimental characterization, theory and simulation on the structures of bilayer membranes or nanoparticles made of lipid mixtures, (2) novel approaches on accessing the functions of biomembranes, and (3) correlation between functions and lipid structures.
Prof. Mu-Ping Nieh
Manuscript Submission Information
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