Alcohol Interactions with Lipid Bilayers§
AbstractWe investigate the structural changes to lipid membrane that ensue from the addition of aliphatic alcohols with various alkyl tail lengths. Small angle neutron diffraction from flat lipid bilayers that are hydrated through water vapor has been employed to eliminate possible artefacts of the membrane curvature and the alcohol’s membrane-water partitioning. We have observed clear changes to membrane structure in both transversal and lateral directions. Most importantly, our results suggest the alteration of the membrane-water interface. The water encroachment has shifted in the way that alcohol loaded bilayers absorbed more water molecules when compared to the neat lipid bilayers. The experimental results have been corroborated by molecular dynamics simulations to reveal further details. Namely, the order parameter profiles have been fruitful in correlating the mechanical model of structural changes to the effect of anesthesia. View Full-Text
Share & Cite This Article
Kondela, T.; Gallová, J.; Hauß, T.; Barnoud, J.; Marrink, S.-J.; Kučerka, N. Alcohol Interactions with Lipid Bilayers. Molecules 2017, 22, 2078.
Kondela T, Gallová J, Hauß T, Barnoud J, Marrink S-J, Kučerka N. Alcohol Interactions with Lipid Bilayers. Molecules. 2017; 22(12):2078.Chicago/Turabian Style
Kondela, Tomáš; Gallová, Jana; Hauß, Thomas; Barnoud, Jonathan; Marrink, Siewert-J.; Kučerka, Norbert. 2017. "Alcohol Interactions with Lipid Bilayers." Molecules 22, no. 12: 2078.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.