Special Issue "Metalloenzyme Inhibitors and Activators"
Deadline for manuscript submissions: closed (28 February 2018)
Prof. Dr. Claudiu T. Supuran
Neurofarba Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Sesto Fiorentino (Florence) 50019, Italy
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Interests: drug design; metalloenzymes; carbonic anhydrases; anticancer agents; antiinfectives; sulfonamides; coumarins
Enzymes have long been considered as important drug targets for the treatment of major human diseases, as several thousands of such proteins are encoded in the human genome, and they play key roles in virtually every physiological/pathological process. Currently, at least 70 human enzymes and 20 bacterial, viral, fungal or parasite enzymes are targets of approved drugs, e.g., up to 40% of the current known drug targets. Enzymes containing metals (metalloenzymes) are of increasing interest and importance, as the genetic and phsysiologic consequences of metalloprotein regulation became better understood processes. All major six enzyme classes established by the International Union of Biochemistry, i.e., oxidoreductases, transferases, hydrolases, lyases, isomerases and ligases have important members among the metalloenzymes known to date. Over the last years, important achievements have been done regarding their characterization, with crucial inhibition/activation studies which led to the identifications of compounds with potential pharmacologic and biotechnologic applications. The present Special Issue of Molecules welcomes contributions dealing with all aspects of metalloenzymes research, including drug design, inhibitors, activators, structure–function relationship, etc.
Prof. Dr. Claudiu T. Supuran
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- enzyme inhibitor
- enzyme activator
- structure-function relationship
- drug design
- metal-binding function