Special Issue "5-Fluorouracil"

Guest Editor
Dr. Francesco Puoci
Dipartimento di Scienze Farmaceutiche, Università della Calabria, Edificio Polifunzionale, Arcavacata di Rende (CS) 87036, Italy
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Interests: molecularly imprinted polymers; functional materials for biomedical applications

Although 5-fluorouracil (5-FU) was first introduced in 1957, it remains one of the most important anticancer agents. In 5-FU, the hydrogen atom at the 5-position of uracil is replaced by a fluorine atom and the molecule was designed to occupy the active sites of enzyme targets, thereby blocking metabolism in malignant cells. Although this antimetabolite is toxic, its efficacy makes it one of the most widely used agents against solid tumors. Numerous reports by the scientific community have been devoted to 5-FU, covering a wide range of topics: preparation of innovative formulations, synthesis of 5-FU derivatives, mechanism of action studies, etc. This special issue of Molecules aims to provide an overview of the current knowledge on this important chemotherapeutic agent, as well as focus on current strategies to improve therapeutic effectiveness of this drug in the treatment of advanced disease.

Guest Editor for this Special Issue
Dr Francesco Puoci

Manuscript Submissions

5-fluorouracil (5-FU), 5-FU analogues, fluorouracil derivatives, prodrugs