Special Issue "5-Fluorouracil"

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A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Synthesis".

Deadline for manuscript submissions: closed (15 October 2008)

Special Issue Editor

Guest Editor
Dr. Francesco Puoci
Dipartimento di Scienze Farmaceutiche, Università della Calabria, Edificio Polifunzionale, Arcavacata di Rende (CS) 87036, Italy
Website: http://www.unical.it/portale/portaltemplates/view/view.cfm?18749
E-Mail: francesco.puoci@unical.it
Phone: +39 0984 493151
Fax: +39 0984 493298
Interests: molecularly imprinted polymers; functional materials for biomedical applications

Special Issue Information

Dear Colleagues,

Although 5-fluorouracil (5-FU) was first introduced in 1957, it remains one of the most important anticancer agents. In 5-FU, the hydrogen atom at the 5-position of uracil is replaced by a fluorine atom and the molecule was designed to occupy the active sites of enzyme targets, thereby blocking metabolism in malignant cells. Although this antimetabolite is toxic, its efficacy makes it one of the most widely used agents against solid tumors. Numerous reports by the scientific community have been devoted to 5-FU, covering a wide range of topics: preparation of innovative formulations, synthesis of 5-FU derivatives, mechanism of action studies, etc. This special issue of Molecules aims to provide an overview of the current knowledge on this important chemotherapeutic agent, as well as focus on current strategies to improve therapeutic effectiveness of this drug in the treatment of advanced disease.

Dr Francesco Puoci
Guest Editor

Keywords

  • 5-fluorouracil (5-FU)
  • 5-FU analogues
  • fluorouracil derivatives
  • prodrugs

Published Papers (8 papers)

by , , , , ,  and
Molecules 2008, 13(7), 1441-1454; doi:10.3390/molecules13071441
Received: 12 June 2008; Accepted: 27 June 2008 / Published: 28 June 2008
Show/Hide Abstract | Cited by 22 | PDF Full-text (199 KB)

by , ,  and
Molecules 2008, 13(8), 1551-1569; doi:10.3390/molecules13081551
Received: 18 June 2008; in revised form: 1 July 2008 / Accepted: 15 July 2008 / Published: 5 August 2008
Show/Hide Abstract | Cited by 35 | PDF Full-text (214 KB)

by , , , ,  and
Molecules 2008, 13(8), 1897-1922; doi:10.3390/molecules13081897
Received: 30 May 2008; in revised form: 15 August 2008 / Accepted: 25 August 2008 / Published: 27 August 2008
Show/Hide Abstract | Cited by 17 | PDF Full-text (289 KB)

by
Molecules 2008, 13(10), 2340-2369; doi:10.3390/molecules13102340
Received: 22 April 2008; in revised form: 16 September 2008 / Accepted: 16 September 2008 / Published: 1 October 2008
Show/Hide Abstract | Cited by 24 | PDF Full-text (717 KB)

by , , ,  and
Molecules 2008, 13(10), 2370-2384; doi:10.3390/molecules13102370
Received: 8 September 2008; in revised form: 22 September 2008 / Accepted: 22 September 2008 / Published: 1 October 2008
Show/Hide Abstract | Cited by 12 | PDF Full-text (248 KB)
abstract graphic

by , , , , ,  and
Molecules 2008, 13(10), 2608-2627; doi:10.3390/molecules13102608
Received: 8 August 2008; in revised form: 16 October 2008 / Accepted: 20 October 2008 / Published: 22 October 2008
Show/Hide Abstract | Cited by 9 | PDF Full-text (462 KB)
abstract graphic

by , , ,  and
Molecules 2008, 13(11), 2729-2739; doi:10.3390/molecules13112729
Received: 8 June 2008; in revised form: 9 October 2008 / Accepted: 24 October 2008 / Published: 1 November 2008
Show/Hide Abstract | Cited by 3 | PDF Full-text (2930 KB)
abstract graphic

by , ,  and
Molecules 2009, 14(1), 53-67; doi:10.3390/molecules14010053
Received: 15 October 2008; in revised form: 21 December 2008 / Accepted: 24 December 2008 / Published: 28 December 2008
Show/Hide Abstract | Cited by 1 | PDF Full-text (889 KB)

Last update: 27 February 2014

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