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Molecules 2008, 13(10), 2370-2384; doi:10.3390/molecules13102370
Review

Radiation- and Photo-induced Activation of 5-Fluorouracil Prodrugs as a Strategy for the Selective Treatment of Solid Tumors

, , ,  and *
Received: 8 September 2008; in revised form: 22 September 2008 / Accepted: 22 September 2008 / Published: 1 October 2008
(This article belongs to the Special Issue 5-Fluorouracil)
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Abstract: 5-Fluorouracil (5-FU) is used widely as an anticancer drug to treat solid cancers, such as colon, breast, rectal, and pancreatic cancers, although its clinical application is limited because 5-FU has gastrointestinal and hematological toxicity. Many groups are searching for prodrugs with functions that are tumor selective in their delivery and can be activated to improve the clinical utility of 5-FU as an important cancer chemotherapeutic agent. UV and ionizing radiation can cause chemical reactions in a localized area of the body, and these have been applied in the development of site-specific drug activation and sensitization. In this review, we describe recent progress in the development of novel 5-FU prodrugs that are activated site specifically by UV light and ionizing radiation in the tumor microenvironment. We also discuss the chemical mechanisms underlying this activation.
Keywords: 5-Fluorouracil; Prodrugs; Hypoxia; Hydrated Electrons; Radiolysis; Photolysis 5-Fluorouracil; Prodrugs; Hypoxia; Hydrated Electrons; Radiolysis; Photolysis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Ito, T.; Tanabe, K.; Yamada, H.; Hatta, H.; Nishimoto, S.-I. Radiation- and Photo-induced Activation of 5-Fluorouracil Prodrugs as a Strategy for the Selective Treatment of Solid Tumors. Molecules 2008, 13, 2370-2384.

AMA Style

Ito T, Tanabe K, Yamada H, Hatta H, Nishimoto S-I. Radiation- and Photo-induced Activation of 5-Fluorouracil Prodrugs as a Strategy for the Selective Treatment of Solid Tumors. Molecules. 2008; 13(10):2370-2384.

Chicago/Turabian Style

Ito, Takeo; Tanabe, Kazuhito; Yamada, Hisatsugu; Hatta, Hiroshi; Nishimoto, Sei-ichi. 2008. "Radiation- and Photo-induced Activation of 5-Fluorouracil Prodrugs as a Strategy for the Selective Treatment of Solid Tumors." Molecules 13, no. 10: 2370-2384.



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