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Molecules 2008, 13(8), 1897-1922; doi:10.3390/molecules13081897

Efficacy of the Oral Fluorouracil Pro-drug Capecitabine in Cancer Treatment: a Review

1,* , 1
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Received: 30 May 2008 / Revised: 15 August 2008 / Accepted: 25 August 2008 / Published: 27 August 2008
(This article belongs to the Special Issue 5-Fluorouracil)
Download PDF [289 KB, uploaded 18 June 2014]
Abstract: Capecitabine (Xeloda®) was developed as a pro-drug of fluorouracil (FU), with the aim of improving tolerability and intratumor drug concentrations through its tumorspecific conversion to the active drug. The purpose of this paper is to review the available information on capecitabine, focusing on its clinical effectiveness against various carcinomas. Identification of all eligible English trails was made by searching the PubMed and Cochrane databases from 1980 to 2007. Search terms included capecitabine, Xeloda and cancer treatment. Nowadays, FDA has approved the use of capecitabine as a first line therapy in patients with metastatic colorectal cancer when single-agent fluoropyrimidine is preferred. The drug is also approved for use as a single agent in metastatic breast cancer patients who are resistant to both anthracycline and paclitaxel-based regimens or when further anthracycline treatment is contraindicated. It is also approved in combination with docetaxel after failure of prior anthracycline-based chemotherapy. In patients with prostate, pancreatic, renal cell and ovarian carcinomas, capecitabine as a single-agent or in combination with other drugs has also shown benefits. Improved tolerability and comparable efficacy, compared with the intravenous FU/LV combination, in addition to its oral administration, make capecitabine an attractive option for the treatment of several types of carcinomas.
Keywords: Capecitabine; Xeloda; cancer treatment Capecitabine; Xeloda; cancer treatment
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Koukourakis, G.V.; Kouloulias, V.; Koukourakis, M.J.; Zacharias, G.A.; Zabatis, H.; Kouvaris, J. Efficacy of the Oral Fluorouracil Pro-drug Capecitabine in Cancer Treatment: a Review. Molecules 2008, 13, 1897-1922.

AMA Style

Koukourakis GV, Kouloulias V, Koukourakis MJ, Zacharias GA, Zabatis H, Kouvaris J. Efficacy of the Oral Fluorouracil Pro-drug Capecitabine in Cancer Treatment: a Review. Molecules. 2008; 13(8):1897-1922.

Chicago/Turabian Style

Koukourakis, Georgios V.; Kouloulias, Vassilios; Koukourakis, Michael J.; Zacharias, Georgios A.; Zabatis, Haralabos; Kouvaris, John. 2008. "Efficacy of the Oral Fluorouracil Pro-drug Capecitabine in Cancer Treatment: a Review." Molecules 13, no. 8: 1897-1922.

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