Special Issue "Protein Crystallography in Molecular Biology 2015"

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A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry, Molecular Biology and Biophysics".

Deadline for manuscript submissions: closed (31 March 2015)

Special Issue Editor

Guest Editor
Prof. Dr. Charles A. Collyer
School of Molecular Bioscience, G08 - Biochemistry Building, The University of Sydney, NSW 2006, Australia
Website: http://sydney.edu.au/medicine/people/academics/profiles/charlesc.php
Interests: protein structure and function; anaerobic bacteria; bacterial adhesins

Special Issue Information

Dear Colleagues,

Our understanding of how biological molecules interact is often presented as a number of snapshots of static images derived from bio-molecular crystallography (today, images are increasingly also derived from NMR spectroscopy). We “see” our molecular biology in these images as processes of recognition, biochemical transformation, physical movement, and communication. Being a sub-nano imaging technique, crystallography provides unbiased insight into the complex features of proteins, DNA, and RNA, and their relationships to substrates, inhibitors, and binding partners. The crystal structures of proteins often surprise us because they produce images of molecules as they really are! Many novel gene products are not structured in the ways that we initially perceive them to be; experimentally determined structures enable us to accurately translate genetic information into three dimensions. By identifying particular structural features of biological molecules and then associating them with specific functions, biologists can focus on mechanistic relationships. Understanding such relationships may enable the construction of working models that can usefully drive studies of complex systems in biology. This type of approach, which uses the identification of key elements of structure to start a tertiary discovery process, has been applied successfully in all the life sciences, from biochemistry to cell biology and beyond (into our understanding of evolution).

This Special Issue on protein crystallography for the International Journal of Molecular Sciences will focus on examples in molecular biology where structural data derived from protein crystallography has provided the means of generating unique insights into molecular processes in biology.

Prof. Dr. Charles A. Collyer
Guest Editor

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs).

Keywords

  • nucleotide sequence recognition
  • structural motifs and function
  • protein families
  • directed evolution and structure
  • structural models and application
  • conformational signaling
  • enzyme mechanism and drug design

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Published Papers (11 papers)

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p. 15971-15984
by , , , ,  and
Int. J. Mol. Sci. 2015, 16(7), 15971-15984; doi:10.3390/ijms160715971
Received: 26 April 2015 / Revised: 4 June 2015 / Accepted: 15 June 2015 / Published: 14 July 2015
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(This article belongs to the Special Issue Protein Crystallography in Molecular Biology 2015)
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p. 15456-15480
by , , ,  and
Int. J. Mol. Sci. 2015, 16(7), 15456-15480; doi:10.3390/ijms160715456
Received: 26 May 2015 / Revised: 1 July 2015 / Accepted: 2 July 2015 / Published: 8 July 2015
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(This article belongs to the Special Issue Protein Crystallography in Molecular Biology 2015)
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p. 15287-15308
by , , , , , , , , , , ,  and
Int. J. Mol. Sci. 2015, 16(7), 15287-15308; doi:10.3390/ijms160715287
Received: 30 March 2015 / Revised: 19 June 2015 / Accepted: 24 June 2015 / Published: 7 July 2015
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(This article belongs to the Special Issue Protein Crystallography in Molecular Biology 2015)
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p. 13004-13022
by ,  and
Int. J. Mol. Sci. 2015, 16(6), 13004-13022; doi:10.3390/ijms160613004
Received: 27 February 2015 / Revised: 24 April 2015 / Accepted: 13 May 2015 / Published: 9 June 2015
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(This article belongs to the Special Issue Protein Crystallography in Molecular Biology 2015)
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p. 13106-13140
by ,  and
Int. J. Mol. Sci. 2015, 16(6), 13106-13140; doi:10.3390/ijms160613106
Received: 31 March 2015 / Accepted: 1 June 2015 / Published: 9 June 2015
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(This article belongs to the Special Issue Protein Crystallography in Molecular Biology 2015)
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p. 12943-12957
by ,  and
Int. J. Mol. Sci. 2015, 16(6), 12943-12957; doi:10.3390/ijms160612943
Received: 1 April 2015 / Revised: 27 May 2015 / Accepted: 28 May 2015 / Published: 8 June 2015
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(This article belongs to the Special Issue Protein Crystallography in Molecular Biology 2015)
p. 9654-9692
by , , , , , ,  and
Int. J. Mol. Sci. 2015, 16(5), 9654-9692; doi:10.3390/ijms16059654
Received: 3 February 2015 / Revised: 21 April 2015 / Accepted: 22 April 2015 / Published: 29 April 2015
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(This article belongs to the Special Issue Protein Crystallography in Molecular Biology 2015)
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p. 3677-3699
by , , , , , , , , ,  and
Int. J. Mol. Sci. 2015, 16(2), 3677-3699; doi:10.3390/ijms16023677
Received: 9 January 2015 / Accepted: 30 January 2015 / Published: 6 February 2015
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(This article belongs to the Special Issue Protein Crystallography in Molecular Biology 2015)
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p. 2269-2293
by ,  and
Int. J. Mol. Sci. 2015, 16(2), 2269-2293; doi:10.3390/ijms16022269
Received: 24 November 2014 / Revised: 9 January 2015 / Accepted: 12 January 2015 / Published: 22 January 2015
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(This article belongs to the Special Issue Protein Crystallography in Molecular Biology 2015)
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p. 1406-1428
by , , ,  and
Int. J. Mol. Sci. 2015, 16(1), 1406-1428; doi:10.3390/ijms16011406
Received: 5 December 2014 / Accepted: 5 January 2015 / Published: 8 January 2015
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(This article belongs to the Special Issue Protein Crystallography in Molecular Biology 2015)
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p. 18253-18266
by ,  and
Int. J. Mol. Sci. 2014, 15(10), 18253-18266; doi:10.3390/ijms151018253
Received: 31 July 2014 / Revised: 23 September 2014 / Accepted: 25 September 2014 / Published: 10 October 2014
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(This article belongs to the Special Issue Protein Crystallography in Molecular Biology 2015)
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Last update: 9 March 2015

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert