Special Issue "Protein Crystallography in Molecular Biology 2015"
Deadline for manuscript submissions: closed (31 March 2015)
Prof. Dr. Charles A. Collyer (Website)
School of Molecular Bioscience, G08 - Biochemistry Building, The University of Sydney, NSW 2006, Australia
Interests: protein structure and function; anaerobic bacteria; bacterial adhesins
Our understanding of how biological molecules interact is often presented as a number of snapshots of static images derived from bio-molecular crystallography (today, images are increasingly also derived from NMR spectroscopy). We “see” our molecular biology in these images as processes of recognition, biochemical transformation, physical movement, and communication. Being a sub-nano imaging technique, crystallography provides unbiased insight into the complex features of proteins, DNA, and RNA, and their relationships to substrates, inhibitors, and binding partners. The crystal structures of proteins often surprise us because they produce images of molecules as they really are! Many novel gene products are not structured in the ways that we initially perceive them to be; experimentally determined structures enable us to accurately translate genetic information into three dimensions. By identifying particular structural features of biological molecules and then associating them with specific functions, biologists can focus on mechanistic relationships. Understanding such relationships may enable the construction of working models that can usefully drive studies of complex systems in biology. This type of approach, which uses the identification of key elements of structure to start a tertiary discovery process, has been applied successfully in all the life sciences, from biochemistry to cell biology and beyond (into our understanding of evolution).
This Special Issue on protein crystallography for the International Journal of Molecular Sciences will focus on examples in molecular biology where structural data derived from protein crystallography has provided the means of generating unique insights into molecular processes in biology.
Prof. Dr. Charles A. Collyer
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed Open Access monthly journal published by MDPI.
- nucleotide sequence recognition
- structural motifs and function
- protein families
- directed evolution and structure
- structural models and application
- conformational signaling
- enzyme mechanism and drug design