Special Issue "Protein Crystallography in Molecular Biology"

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A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry, Molecular Biology and Biophysics".

Deadline for manuscript submissions: closed (31 May 2012)

Special Issue Editor

Guest Editor
Prof. Dr. Charles A. Collyer
School of Molecular Bioscience, G08 - Biochemistry Building, The University of Sydney, NSW 2006, Australia
Website: http://sydney.edu.au/medicine/people/academics/profiles/charlesc.php
E-Mail: charlesacollyer@gmail.com
Interests: protein structure and function; anaerobic bacteria; bacterial adhesins

Special Issue Information

Dear Colleagues,

Our understanding of how biological molecules interact is often presented as a number of snapshots of static images derived from bio-molecular crystallography (and today increasingly derived also from NMR spectroscopy). We “see” our molecular biology in these images as processes of recognition, biochemical transformation, physical movement and communication. Being an imaging technique it provides unbiased insights into the complex features of proteins, DNA, RNA, and their relationship to substrates, inhibitors and binding partners. Crystal structures of proteins often surprise as they produce images of molecules as they really are! Many novel gene products are not structured how we initially perceive them to be but experimentally determined structures enable us to accurately delineate the genetic information into three dimensions. By identifying particular structural features of biological molecules with specific functions biologists can be led to focus on mechanistic relationships and then to create working models that can usefully drive studies of complex systems in biology. This type of approach using the identification of key elements of structure to start this discovery process has had application in all of biology, from genetics to cell biology and then beyond into our understanding of evolution.

This special issue on protein crystallography for the International Journal of Molecular Sciences will focus on examples in molecular biology where structural data derived from protein crystallography has “turned heads” and then provided the means to generate unique insights into molecular processes in biology.

Prof. Dr. Charles A. Collyer
Guest Editor

Keywords

  • Sub-domain structure
  • structural motifs
  • protein families
  • protein/nucleic acid recognition
  • structural model
  • conformational signalling
  • enzyme mechanism
  • activation
  • inhibition
  • regulation

Related Special Issue

Published Papers (15 papers)

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p. 12761-12772
by  and
Int. J. Mol. Sci. 2012, 13(10), 12761-12772; doi:10.3390/ijms131012761
Received: 11 September 2012; in revised form: 21 September 2012 / Accepted: 21 September 2012 / Published: 8 October 2012
Show/Hide Abstract | Cited by 2 | PDF Full-text (664 KB) | HTML Full-text | XML Full-text | Supplementary Files
(This article belongs to the Special Issue Protein Crystallography in Molecular Biology)
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p. 12857-12879
by ,  and
Int. J. Mol. Sci. 2012, 13(10), 12857-12879; doi:10.3390/ijms131012857
Received: 4 July 2012; in revised form: 30 August 2012 / Accepted: 19 September 2012 / Published: 8 October 2012
Show/Hide Abstract | Cited by 7 | PDF Full-text (802 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Protein Crystallography in Molecular Biology)
p. 10537-10552
by , , , ,  and
Int. J. Mol. Sci. 2012, 13(8), 10537-10552; doi:10.3390/ijms130810537
Received: 31 May 2012; in revised form: 9 August 2012 / Accepted: 17 August 2012 / Published: 22 August 2012
Show/Hide Abstract | Cited by 7 | PDF Full-text (1413 KB) | HTML Full-text | XML Full-text | Supplementary Files
(This article belongs to the Special Issue Protein Crystallography in Molecular Biology)
p. 10553-10567
by , , , , , , ,  and
Int. J. Mol. Sci. 2012, 13(8), 10553-10567; doi:10.3390/ijms130810553
Received: 1 June 2012; in revised form: 2 August 2012 / Accepted: 3 August 2012 / Published: 22 August 2012
Show/Hide Abstract | Cited by 5 | PDF Full-text (4962 KB) | HTML Full-text | XML Full-text | Supplementary Files
(This article belongs to the Special Issue Protein Crystallography in Molecular Biology)
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p. 10268-10295
by ,  and
Int. J. Mol. Sci. 2012, 13(8), 10268-10295; doi:10.3390/ijms130810268
Received: 30 May 2012; in revised form: 17 July 2012 / Accepted: 2 August 2012 / Published: 17 August 2012
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(This article belongs to the Special Issue Protein Crystallography in Molecular Biology)
p. 10010-10021
by , , , ,  and
Int. J. Mol. Sci. 2012, 13(8), 10010-10021; doi:10.3390/ijms130810010
Received: 4 June 2012; in revised form: 24 July 2012 / Accepted: 26 July 2012 / Published: 10 August 2012
Show/Hide Abstract | Cited by 1 | PDF Full-text (766 KB) | HTML Full-text | XML Full-text | Supplementary Files
(This article belongs to the Special Issue Protein Crystallography in Molecular Biology)
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p. 9514-9526
by , , ,  and
Int. J. Mol. Sci. 2012, 13(8), 9514-9526; doi:10.3390/ijms13089514
Received: 1 June 2012; in revised form: 9 July 2012 / Accepted: 10 July 2012 / Published: 27 July 2012
Show/Hide Abstract | Cited by 1 | PDF Full-text (469 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Protein Crystallography in Molecular Biology)
p. 9207-9217
by , ,  and
Int. J. Mol. Sci. 2012, 13(7), 9207-9217; doi:10.3390/ijms13079207
Received: 16 May 2012; in revised form: 29 June 2012 / Accepted: 12 July 2012 / Published: 23 July 2012
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(This article belongs to the Special Issue Protein Crystallography in Molecular Biology)
p. 8500-8513
by , , , , ,  and
Int. J. Mol. Sci. 2012, 13(7), 8500-8513; doi:10.3390/ijms13078500
Received: 1 June 2012; in revised form: 22 June 2012 / Accepted: 28 June 2012 / Published: 9 July 2012
Show/Hide Abstract | Cited by 4 | PDF Full-text (375 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Protein Crystallography in Molecular Biology)
p. 8398-8429
by  and
Int. J. Mol. Sci. 2012, 13(7), 8398-8429; doi:10.3390/ijms13078398
Received: 31 May 2012; in revised form: 18 June 2012 / Accepted: 28 June 2012 / Published: 6 July 2012
Show/Hide Abstract | Cited by 11 | PDF Full-text (3679 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Protein Crystallography in Molecular Biology)
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p. 8025-8037
by , , , , ,  and
Int. J. Mol. Sci. 2012, 13(7), 8025-8037; doi:10.3390/ijms13078025
Received: 31 May 2012; in revised form: 14 June 2012 / Accepted: 15 June 2012 / Published: 28 June 2012
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(This article belongs to the Special Issue Protein Crystallography in Molecular Biology)
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p. 6711-6729
by ,  and
Int. J. Mol. Sci. 2012, 13(6), 6711-6729; doi:10.3390/ijms13066711
Received: 20 April 2012; in revised form: 14 May 2012 / Accepted: 24 May 2012 / Published: 1 June 2012
Show/Hide Abstract | Cited by 4 | PDF Full-text (2831 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Protein Crystallography in Molecular Biology)
p. 5375-5405
by  and
Int. J. Mol. Sci. 2012, 13(5), 5375-5405; doi:10.3390/ijms13055375
Received: 6 April 2012; in revised form: 22 April 2012 / Accepted: 26 April 2012 / Published: 3 May 2012
Show/Hide Abstract | Cited by 5 | PDF Full-text (1105 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Protein Crystallography in Molecular Biology)
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p. 4807-4818
by
Int. J. Mol. Sci. 2012, 13(4), 4807-4818; doi:10.3390/ijms13044807
Received: 7 March 2012; in revised form: 28 March 2012 / Accepted: 10 April 2012 / Published: 16 April 2012
Show/Hide Abstract | Cited by 12 | PDF Full-text (406 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Protein Crystallography in Molecular Biology)
p. 943-960
by , , , ,  and
Int. J. Mol. Sci. 2012, 13(1), 943-960; doi:10.3390/ijms13010943
Received: 8 October 2011; in revised form: 25 November 2011 / Accepted: 28 November 2011 / Published: 17 January 2012
Show/Hide Abstract | Cited by 5 | PDF Full-text (1631 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Protein Crystallography in Molecular Biology)
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Last update: 26 February 2014

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