The N-Acetylglutamate Synthase Family: Structures, Function and Mechanisms
AbstractN-acetylglutamate synthase (NAGS) catalyzes the production of N-acetylglutamate (NAG) from acetyl-CoA and l-glutamate. In microorganisms and plants, the enzyme functions in the arginine biosynthetic pathway, while in mammals, its major role is to produce the essential co-factor of carbamoyl phosphate synthetase 1 (CPS1) in the urea cycle. Recent work has shown that several different genes encode enzymes that can catalyze NAG formation. A bifunctional enzyme was identified in certain bacteria, which catalyzes both NAGS and N-acetylglutamate kinase (NAGK) activities, the first two steps of the arginine biosynthetic pathway. Interestingly, these bifunctional enzymes have higher sequence similarity to vertebrate NAGS than those of the classical (mono-functional) bacterial NAGS. Solving the structures for both classical bacterial NAGS and bifunctional vertebrate-like NAGS/K has advanced our insight into the regulation and catalytic mechanisms of NAGS, and the evolutionary relationship between the two NAGS groups. View Full-Text
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Shi, D.; Allewell, N.M.; Tuchman, M. The N-Acetylglutamate Synthase Family: Structures, Function and Mechanisms. Int. J. Mol. Sci. 2015, 16, 13004-13022.
Shi D, Allewell NM, Tuchman M. The N-Acetylglutamate Synthase Family: Structures, Function and Mechanisms. International Journal of Molecular Sciences. 2015; 16(6):13004-13022.Chicago/Turabian Style
Shi, Dashuang; Allewell, Norma M.; Tuchman, Mendel. 2015. "The N-Acetylglutamate Synthase Family: Structures, Function and Mechanisms." Int. J. Mol. Sci. 16, no. 6: 13004-13022.