Special Issue "Biologic Coatings for Orthopaedic Implant"


A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Material Sciences and Nanotechnology".

Deadline for manuscript submissions: 25 April 2014

Special Issue Editor

Guest Editor
Prof. Dr. Stuart Goodman
Department of Orthopaedic Surgery, Stanford University, Stanford, CA, USA
Website: http://biodesign.stanford.edu/bdn/people/sgoodman.jsp
E-Mail: goodbone@stanford.edu

Special Issue Information

Dear Colleagues,

Devices are commonly implanted during orthopaedic surgical procedures for fracture fixation, spine stabilization, total joint replacement and in numerous other subspecialties. Traditionally these implants have been made of non-biodegradable metals, polymer, and ceramics, and more recently, fully or partially biodegradable materials. These devices must interact with host tissues to obtain a final desired clinical goal with few or no adverse events. More recently, it has been realized that surface modifications and coatings of an orthopaedic device may improve the chances of achieving the desired outcome. Examples include coating of devices implanted into bone with bioceramics, growth factors and other molecules to accelerate fixation and implant osseointegration, coatings that deliver molecules to prevent or combat infection and composite tissue coated implants.

This special issue on "Biologic Coatings for Orthopaedic Implants" for the International Journal of Molecular Sciences will focus on such novel coatings for orthopaedic implants, including basic and applied science and their potential clinical application. This information will help further the scientific principles underlying coating technology and their applications in the hope that patient care will be enhanced.

Prof. Dr. Stuart Goodman
Guest Editor


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs).


  • orthopaedic surgery
  • implant coatings
  • osseointegration
  • orthopaedic infection
  • surface modification

Published Papers (4 papers)

Int. J. Mol. Sci. 2014, 15(4), 5426-5445; doi:10.3390/ijms15045426
Received: 3 January 2014; in revised form: 14 March 2014 / Accepted: 24 March 2014 / Published: 28 March 2014
Show/Hide Abstract | Download PDF Full-text (376 KB)

Int. J. Mol. Sci. 2014, 15(2), 2454-2464; doi:10.3390/ijms15022454
Received: 30 December 2013; in revised form: 27 January 2014 / Accepted: 30 January 2014 / Published: 11 February 2014
Show/Hide Abstract | Download PDF Full-text (473 KB) | Download XML Full-text

Int. J. Mol. Sci. 2013, 14(12), 24366-24379; doi:10.3390/ijms141224366
Received: 16 November 2013; in revised form: 5 December 2013 / Accepted: 11 December 2013 / Published: 13 December 2013
Show/Hide Abstract | Download PDF Full-text (635 KB) | View HTML Full-text | Download XML Full-text

Int. J. Mol. Sci. 2013, 14(9), 19155-19168; doi:10.3390/ijms140919155
Received: 28 August 2013; in revised form: 8 September 2013 / Accepted: 11 September 2013 / Published: 17 September 2013
Show/Hide Abstract | Download PDF Full-text (1352 KB) | Download XML Full-text

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Type of Paper: Article
Osseointegration of Bioactive Plasma-Polymerized Implant Surfaces in an Animal Model
: Carolin Gabler, Carmen Zietz, Rainer Bader et al.
Department of Orthopaedics, University Medicine Rostock, Germany
: Objective: Due to plasma polymerization it is possible to apply positively charged, nanometer thin coatings to the implant surfaces for the enhancement of adhesion and ingrowth of osteoblasts. The aim of the present study was to evaluate the osseointegration and bone-to-implant contact of implants coated with bioactive plasma polymers using an animal model. Materials and Methods: Custom-made conical titanium implants with a rough surface (Rz=20µm) were inserted at the tibia of female Sprague-Dawley rats. Three implant configurations were examined: uncoated, coated with plasma-polymerized allylamine (PPAAm) and coated with plasma-polymerized ethylendiamine (PPEDA). Animals were sacrificed after six weeks. Bone-to-implant contact was determined by means of histomorphometry. Results:The data indicate the tendency that the implants with plasma-polymerized coatings (PPAAm and PPEDA) lead to higher bone-to-implant contact compared to the uncoated TiAl4V implant. Conclusion:With respect to previous cell investigations we can demonstrate an advanced ongrowth of bone cells on PPAAm or PPEDA coated surfaces in animal experiments. Plasma polymer coatings reveal positive influence on “race for the surface” of bone cells and therefore should have beneficial effects on the osseointegration of titanium implants in clinical application.
implant coating; plasma polymerization; animal experiment; osseointegration

Last update: 9 January 2014

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