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Int. J. Mol. Sci. 2014, 15(6), 10150-10168; doi:10.3390/ijms150610150
Review

BMP-Functionalised Coatings to Promote Osteogenesis for Orthopaedic Implants

1
, 2
, 1
, 1,*  and 1,3,*
Received: 17 April 2014; in revised form: 13 May 2014 / Accepted: 22 May 2014 / Published: 6 June 2014
(This article belongs to the Special Issue Biologic Coatings for Orthopaedic Implant)
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Abstract: The loss of bone integrity can significantly compromise the aesthetics and mobility of patients and can be treated using orthopaedic implants. Over the past decades; various orthopaedic implants; such as allografts; xenografts and synthetic materials; have been developed and widely used in clinical practice. However; most of these materials lack intrinsic osteoinductivity and thus cannot induce bone formation. Consequently; osteoinductive functionalisation of orthopaedic implants is needed to promote local osteogenesis and implant osteointegration. For this purpose; bone morphogenetic protein (BMP)-functionalised coatings have proven to be a simple and effective strategy. In this review; we summarise the current knowledge and recent advances regarding BMP-functionalised coatings for orthopaedic implants.
Keywords: bone morphogenetic protein; coating; orthopaedic implant; osteogenesis bone morphogenetic protein; coating; orthopaedic implant; osteogenesis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wang, J.; Guo, J.; Liu, J.; Wei, L.; Wu, G. BMP-Functionalised Coatings to Promote Osteogenesis for Orthopaedic Implants. Int. J. Mol. Sci. 2014, 15, 10150-10168.

AMA Style

Wang J, Guo J, Liu J, Wei L, Wu G. BMP-Functionalised Coatings to Promote Osteogenesis for Orthopaedic Implants. International Journal of Molecular Sciences. 2014; 15(6):10150-10168.

Chicago/Turabian Style

Wang, Jianfeng; Guo, Jing; Liu, Jingsong; Wei, Limin; Wu, Gang. 2014. "BMP-Functionalised Coatings to Promote Osteogenesis for Orthopaedic Implants." Int. J. Mol. Sci. 15, no. 6: 10150-10168.



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