Int. J. Mol. Sci. 2014, 15(2), 2454-2464; doi:10.3390/ijms15022454

Evaluation of Osseointegration of Titanium Alloyed Implants Modified by Plasma Polymerization

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Received: 30 December 2013; in revised form: 27 January 2014 / Accepted: 30 January 2014 / Published: 11 February 2014
(This article belongs to the Special Issue Biologic Coatings for Orthopaedic Implant)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: By means of plasma polymerization, positively charged, nanometre-thin coatings can be applied to implant surfaces. The aim of the present study was to quantify the adhesion of human bone cells in vitro and to evaluate the bone ongrowth in vivo, on titanium surfaces modified by plasma polymer coatings. Different implant surface configurations were examined: titanium alloy (Ti6Al4V) coated with plasma-polymerized allylamine (PPAAm) and plasma-polymerized ethylenediamine (PPEDA) versus uncoated. Shear stress on human osteoblast-like MG-63 cells was investigated in vitro using a spinning disc device. Furthermore, bone-to-implant contact (BIC) was evaluated in vivo. Custom-made conical titanium implants were inserted at the medial tibia of female Sprague-Dawley rats. After a follow-up of six weeks, the BIC was determined by means of histomorphometry. The quantification of cell adhesion showed a significantly higher shear stress for MG-63 cells on PPAAm and PPEDA compared to uncoated Ti6Al4V. Uncoated titanium alloyed implants showed the lowest BIC (40.4%). Implants with PPAAm coating revealed a clear but not significant increase of the BIC (58.5%) and implants with PPEDA a significantly increased BIC (63.7%). In conclusion, plasma polymer coatings demonstrate enhanced cell adhesion and bone ongrowth compared to uncoated titanium surfaces.
Keywords: implant coating; plasma polymerization; cell adhesion; animal experiment; osseointegration
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MDPI and ACS Style

Gabler, C.; Zietz, C.; Göhler, R.; Fritsche, A.; Lindner, T.; Haenle, M.; Finke, B.; Meichsner, J.; Lenz, S.; Frerich, B.; Lüthen, F.; Nebe, J.B.; Bader, R. Evaluation of Osseointegration of Titanium Alloyed Implants Modified by Plasma Polymerization. Int. J. Mol. Sci. 2014, 15, 2454-2464.

AMA Style

Gabler C, Zietz C, Göhler R, Fritsche A, Lindner T, Haenle M, Finke B, Meichsner J, Lenz S, Frerich B, Lüthen F, Nebe JB, Bader R. Evaluation of Osseointegration of Titanium Alloyed Implants Modified by Plasma Polymerization. International Journal of Molecular Sciences. 2014; 15(2):2454-2464.

Chicago/Turabian Style

Gabler, Carolin; Zietz, Carmen; Göhler, Rebecca; Fritsche, Andreas; Lindner, Tobias; Haenle, Maximilian; Finke, Birgit; Meichsner, Jürgen; Lenz, Solvig; Frerich, Bernhard; Lüthen, Frank; Nebe, J. B.; Bader, Rainer. 2014. "Evaluation of Osseointegration of Titanium Alloyed Implants Modified by Plasma Polymerization." Int. J. Mol. Sci. 15, no. 2: 2454-2464.

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