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Int. J. Mol. Sci. 2014, 15(2), 2454-2464; doi:10.3390/ijms15022454

Evaluation of Osseointegration of Titanium Alloyed Implants Modified by Plasma Polymerization

1
Biomechanics and Implant Technology Research Laboratory, Department of Orthopaedics, University Medical Center Rostock, Doberaner Straße 142, 18057 Rostock, Germany
2
Leibniz Institute for Plasma Science and Technology (INP e.V.) Greifswald, Felix-Hausdorff-Str. 2, 17489 Greifswald, Germany
3
Institute of Physics, University of Greifswald, Felix-Hausdorff-Str. 6, 17487 Greifswald, Germany
4
Department of Oral and Maxillofacial Surgery, University Medical Center Rostock, Schillingallee 35, 18057 Rostock, Germany
5
Department of Cell Biology, University Medical Center Rostock, Schillingallee 69, 18057 Rostock, Germany
*
Author to whom correspondence should be addressed.
Received: 30 December 2013 / Revised: 27 January 2014 / Accepted: 30 January 2014 / Published: 11 February 2014
(This article belongs to the Special Issue Biologic Coatings for Orthopaedic Implant)
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Abstract

By means of plasma polymerization, positively charged, nanometre-thin coatings can be applied to implant surfaces. The aim of the present study was to quantify the adhesion of human bone cells in vitro and to evaluate the bone ongrowth in vivo, on titanium surfaces modified by plasma polymer coatings. Different implant surface configurations were examined: titanium alloy (Ti6Al4V) coated with plasma-polymerized allylamine (PPAAm) and plasma-polymerized ethylenediamine (PPEDA) versus uncoated. Shear stress on human osteoblast-like MG-63 cells was investigated in vitro using a spinning disc device. Furthermore, bone-to-implant contact (BIC) was evaluated in vivo. Custom-made conical titanium implants were inserted at the medial tibia of female Sprague-Dawley rats. After a follow-up of six weeks, the BIC was determined by means of histomorphometry. The quantification of cell adhesion showed a significantly higher shear stress for MG-63 cells on PPAAm and PPEDA compared to uncoated Ti6Al4V. Uncoated titanium alloyed implants showed the lowest BIC (40.4%). Implants with PPAAm coating revealed a clear but not significant increase of the BIC (58.5%) and implants with PPEDA a significantly increased BIC (63.7%). In conclusion, plasma polymer coatings demonstrate enhanced cell adhesion and bone ongrowth compared to uncoated titanium surfaces. View Full-Text
Keywords: implant coating; plasma polymerization; cell adhesion; animal experiment; osseointegration implant coating; plasma polymerization; cell adhesion; animal experiment; osseointegration
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Gabler, C.; Zietz, C.; Göhler, R.; Fritsche, A.; Lindner, T.; Haenle, M.; Finke, B.; Meichsner, J.; Lenz, S.; Frerich, B.; Lüthen, F.; Nebe, J.B.; Bader, R. Evaluation of Osseointegration of Titanium Alloyed Implants Modified by Plasma Polymerization. Int. J. Mol. Sci. 2014, 15, 2454-2464.

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