Int. J. Mol. Sci. 2014, 15(4), 5426-5445; doi:10.3390/ijms15045426

Current Strategies to Improve the Bioactivity of PEEK

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Received: 3 January 2014; in revised form: 14 March 2014 / Accepted: 24 March 2014 / Published: 28 March 2014
(This article belongs to the Special Issue Biologic Coatings for Orthopaedic Implant)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The synthetic thermoplastic polymer polyetheretherketone (PEEK) is becoming a popular component of clinical orthopedic and spinal applications, but its practical use suffers from several limitations. Although PEEK is biocompatible, chemically stable, radiolucent and has an elastic modulus similar to that of normal human bone, it is biologically inert, preventing good integration with adjacent bone tissues upon implantation. Recent efforts have focused on increasing the bioactivity of PEEK to improve the bone-implant interface. Two main strategies have been used to overcome the inert character of PEEK. One approach is surface modification to activate PEEK through surface treatment alone or in combination with a surface coating. Another strategy is to prepare bioactive PEEK composites by impregnating bioactive materials into PEEK substrate. Researchers believe that modified bioactive PEEK will have a wide range of orthopedic applications.
Keywords: polyetheretherketone; bioactivity; surface modification; coating; composite
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MDPI and ACS Style

Ma, R.; Tang, T. Current Strategies to Improve the Bioactivity of PEEK. Int. J. Mol. Sci. 2014, 15, 5426-5445.

AMA Style

Ma R, Tang T. Current Strategies to Improve the Bioactivity of PEEK. International Journal of Molecular Sciences. 2014; 15(4):5426-5445.

Chicago/Turabian Style

Ma, Rui; Tang, Tingting. 2014. "Current Strategies to Improve the Bioactivity of PEEK." Int. J. Mol. Sci. 15, no. 4: 5426-5445.

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