Int. J. Mol. Sci. 2014, 15(7), 12998-13009; doi:10.3390/ijms150712998
Article

Improved Fibroblast Functionalities by Microporous Pattern Fabricated by Microelectromechanical Systems

1email, 2,* email, 3email, 4email and 4,* email
Received: 4 May 2014; in revised form: 31 May 2014 / Accepted: 9 July 2014 / Published: 22 July 2014
(This article belongs to the Special Issue Biologic Coatings for Orthopaedic Implant)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Fibroblasts, which play an important role in biological seal formation and maintenance, determine the long-term success of percutaneous implants. In this study, well-defined microporous structures with micropore diameters of 10–60 µm were fabricated by microelectromechanical systems and their influence on the fibroblast functionalities was observed. The results show that the microporous structures with micropore diameters of 10–60 µm did not influence the initial adherent fibroblast number; however, those with diameters of 40 and 50 µm improved the spread, actin stress fiber organization, proliferation and fibronectin secretion of the fibroblasts. The microporous structures with micropore diameters of 40–50 µm may be promising for application in the percutaneous part of an implant.
Keywords: fibroblasts; microelectromechanical systems; percutaneous implant; microporous structure; surface modification
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MDPI and ACS Style

Wei, H.; Zhao, L.; Chen, B.; Bai, S.; Zhao, Y. Improved Fibroblast Functionalities by Microporous Pattern Fabricated by Microelectromechanical Systems. Int. J. Mol. Sci. 2014, 15, 12998-13009.

AMA Style

Wei H, Zhao L, Chen B, Bai S, Zhao Y. Improved Fibroblast Functionalities by Microporous Pattern Fabricated by Microelectromechanical Systems. International Journal of Molecular Sciences. 2014; 15(7):12998-13009.

Chicago/Turabian Style

Wei, Hongbo; Zhao, Lingzhou; Chen, Bangdao; Bai, Shizhu; Zhao, Yimin. 2014. "Improved Fibroblast Functionalities by Microporous Pattern Fabricated by Microelectromechanical Systems." Int. J. Mol. Sci. 15, no. 7: 12998-13009.

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