Special Issue "Molecular Classification of Human Cancer and Its Role in Tailored Cancer Therapy"


A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Diagnostics".

Deadline for manuscript submissions: 30 September 2014

Special Issue Editor

Guest Editor
Dr. William Chi-shing Cho
Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong
E-Mail: williamcscho@gmail.com
Interests: cancer biomarker; Chinese medicine; diabetes mellitus; evidence-based medicine; genomics; microRNA; molecular diagnostics; nasopharyngeal carcinoma; non-small cell lung cancer; proteomics

Special Issue Information

Dear Colleagues,

Human cancer has an increasing incidence and high mortality worldwide. The traditional diagnostic practice for this disease is based on histological patterns. Recent researches support the notion that cancer is not a single malignant disorder but rather a group of distinct molecular diseases. In the era of precision medicine with targeted therapies, there is an imperative need to overcome the limitations of the conventional classification system to accurately stratify patients to achieve maximum therapeutic efficacy. As such, many molecular diagnostic tests have been developed to identify the underlying genetic signatures and incorporate them into the conventional histopathological classification of cancer. Profiling of cancer has yielded a number of genetic, microRNA and proteomic markers for molecular classification. Newer approaches include, but are not limited to, cancer stem cells analysis and next-generation sequencing. Indeed, molecular classification has already been extensively applied to some types of cancer, such as the subtypes of luminal A and lumina B estrogen receptor-positive breast cancer, the subtypes of ALK- and EGFR-positive non-small cell lung cancer, the subtypes of WNT pathway and Sonic Hedgehog pathway medulloblastoma, etc. This special issue discusses the significance of molecular classification and its impact on the clinical setting for directing rational cancer therapy.

Dr. William Chi-shing Cho
Guest Editor


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs).


  • cancer biomarker
  • cancer stem cells
  • clinical trial
  • copy number variation
  • cytogenetics
  • diagnostic imaging
  • digital PCR
  • epigenomics
  • fluorescence in situ hybridization
  • genome-wide association studies
  • genomic database
  • genomics
  • immunohistochemistry
  • metabolomics
  • methylation
  • microarray
  • microfluidics, nanofluidics
  • microRNA
  • molecular classification
  • molecular diagnostics
  • molecular tumor pathology
  • next-generation sequencing
  • non-coding RNAs
  • omics
  • PCR array
  • personalized medicine
  • post-translational modifications
  • precision medicine
  • proteomics
  • single nucleotide polymorphism
  • targeted therapy
  • theranostics
  • translational cancer research

Published Papers (5 papers)

Int. J. Mol. Sci. 2014, 15(7), 12764-12777; doi:10.3390/ijms150712764
Received: 26 April 2014; in revised form: 30 June 2014 / Accepted: 9 July 2014 / Published: 18 July 2014
Show/Hide Abstract | PDF Full-text (731 KB)

Int. J. Mol. Sci. 2014, 15(7), 11220-11233; doi:10.3390/ijms150711220
Received: 23 April 2014; in revised form: 30 May 2014 / Accepted: 3 June 2014 / Published: 25 June 2014
Show/Hide Abstract | PDF Full-text (786 KB) | Supplementary Files

Int. J. Mol. Sci. 2014, 15(5), 8699-8712; doi:10.3390/ijms15058699
Received: 28 January 2014; in revised form: 4 May 2014 / Accepted: 5 May 2014 / Published: 15 May 2014
Show/Hide Abstract | PDF Full-text (709 KB) | HTML Full-text | XML Full-text

Int. J. Mol. Sci. 2014, 15(3), 4031-4048; doi:10.3390/ijms15034031
Received: 17 January 2014; in revised form: 18 February 2014 / Accepted: 19 February 2014 / Published: 5 March 2014
Show/Hide Abstract | PDF Full-text (1838 KB) | HTML Full-text | XML Full-text | Supplementary Files

Int. J. Mol. Sci. 2014, 15(2), 2876-2891; doi:10.3390/ijms15022876
Received: 24 December 2013; in revised form: 13 February 2014 / Accepted: 17 February 2014 / Published: 19 February 2014
Show/Hide Abstract | Cited by 1 | PDF Full-text (707 KB) | HTML Full-text | XML Full-text

Last update: 6 January 2014

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