Next Article in Journal
Cordycepin Down-Regulates Multiple Drug Resistant (MDR)/HIF-1α through Regulating AMPK/mTORC1 Signaling in GBC-SD Gallbladder Cancer Cells
Next Article in Special Issue
Coexistence of Granular Cell Tumor and Invasive Ductal Breast Cancer in Contralateral Breasts: A Case Report
Previous Article in Journal
S-(−)-10,11-Dihydroxyfarnesoic Acid Methyl Ester Inhibits Melanin Synthesis in Murine Melanocyte Cells
Previous Article in Special Issue
The REST Gene Signature Predicts Drug Sensitivity in Neuroblastoma Cell Lines and Is Significantly Associated with Neuroblastoma Tumor Stage
Article Menu

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2014, 15(7), 12764-12777; doi:10.3390/ijms150712764

Clinical Significance of POU5F1P1 rs10505477 Polymorphism in Chinese Gastric Cancer Patients Receving Cisplatin-Based Chemotherapy after Surgical Resection

1
Department of Oncology, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing 210006, China
2
Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, 818 East Tianyuan Road, Nanjing 211166, China
3
Department of Genetic Toxicology, the Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, 818 East Tianyuan Road, Jiangning District, Nanjing 211166, China
4
Department of Oncology, Nantong Tumor Hospital, Nantong 226000, 30 Tongyang North Road, China
5
Department of Surgery, Yixing People's Hospital, 75 Tongzhenguan Road, Yixing 214200, China
6
Department of General Surgery, Yixing Tumor Hospital, 45 Dongshan East Road, Yixing 214200, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 26 April 2014 / Revised: 30 June 2014 / Accepted: 9 July 2014 / Published: 18 July 2014
View Full-Text   |   Download PDF [731 KB, uploaded 18 July 2014]   |  

Abstract

This study aimed to investigate the association between POU class5 homeobox 1 pseudogene 1 gene (POU5F1P1) rs10505477 polymorphism and the prognosis of Chinese gastric cancer patients, who received cisplatin-based chemotherapy after surgical resection. POU5F1P1 rs10505477 was genotyped using the SNaPshot method in 944 gastric cancer patients who received gastrectomy. The association of rs10505477 G > A polymorphism with the progression and prognosis in gastric cancer patients was statistically analyzed using the SPSS version 18.0 for Windows. The results reveal that rs10505477 polymorphism has a negatively effect on the overall survival of gastric cancer patients in cisplatin-based chemotherapy subgroup (HR = 1.764, 95% CI = 1.069–2.911, p = 0.023). Our preliminary study indicates for the first time that POU5F1P1 rs10505477 is correlated with survival of gastric cancer patients who receving cisplatin-based chemotherapy after gastrectomy. Further studies are warranted to investigate the mechanism and to verify our results in different populations. View Full-Text
Keywords: gastric cancer; POU5F1P1 rs10505477 polymorphism; single nucleotide polymorphism (SNP); cisplatin-based chemotherapy gastric cancer; POU5F1P1 rs10505477 polymorphism; single nucleotide polymorphism (SNP); cisplatin-based chemotherapy
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Shen, L.; Du, M.; Wang, C.; Gu, D.; Wang, M.; Zhang, Q.; Zhao, T.; Zhang, X.; Tan, Y.; Huo, X.; Gong, W.; Xu, Z.; Chen, J.; Zhang, Z. Clinical Significance of POU5F1P1 rs10505477 Polymorphism in Chinese Gastric Cancer Patients Receving Cisplatin-Based Chemotherapy after Surgical Resection. Int. J. Mol. Sci. 2014, 15, 12764-12777.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top