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Int. J. Mol. Sci. 2014, 15(5), 8699-8712; doi:10.3390/ijms15058699
Article

Expression and Effects of High-Mobility Group Box 1 in Cervical Cancer

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Received: 28 January 2014; in revised form: 4 May 2014 / Accepted: 5 May 2014 / Published: 15 May 2014
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Abstract: We investigated the significance of high- mobility group box1 (HMGB1) and T-cell-mediated immunity and prognostic value in cervical cancer. HMGB1, forkhead/winged helix transcription factor p3 (Foxp3), IL-2, and IL-10 protein expression was analyzed in 100 cervical tissue samples including cervical cancer, cervical intraepithelial neoplasia (CIN), and healthy control samples using immunohistochemistry. Serum squamous cell carcinoma antigen (SCC-Ag) was immunoradiometrically measured in 32 serum samples from 37 cases of squamous cervical cancer. HMGB1 and SCC-Ag were then correlated to clinicopathological characteristics. HMGB1 expression tends to increase as cervical cancer progresses and it was found to be significantly correlated to FIGO stage and lymph node metastasis. These findings suggest that HMGB1 may be a useful prognostic indicator of cervical carcinoma. In addition, there were significant positive relationships between HMGB1 and FOXP3 or IL-10 expression (both p < 0.05). In contrast, HMGB1 and IL-2 expression was negatively correlated (p < 0.05). HMGB1 expression may activate Tregs or facilitate Th2 polarization to promote immune evasion of cervical cancer. Elevated HMGB1 protein in cervical carcinoma samples was associated with a high recurrence of HPV infection in univariate analysis (p < 0.05). HMGB1 expression and levels of SCC-Ag were directly correlated in SCC (p < 0.05). Thus, HMGB1 may be a useful biomarker for patient prognosis and cervical cancer prediction and treatment.
Keywords: high-mobility group box 1 protein (HMGB1); regulatory T cells (Tregs); cervical cancer; forkhead/winged helix transcription factor p3 (Foxp3); immunosuppression; serum squamous cell carcinoma antigen (SCC-Ag) high-mobility group box 1 protein (HMGB1); regulatory T cells (Tregs); cervical cancer; forkhead/winged helix transcription factor p3 (Foxp3); immunosuppression; serum squamous cell carcinoma antigen (SCC-Ag)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Pang, X.; Zhang, Y.; Wei, H.; Zhang, J.; Luo, Q.; Huang, C.; Zhang, S. Expression and Effects of High-Mobility Group Box 1 in Cervical Cancer. Int. J. Mol. Sci. 2014, 15, 8699-8712.

AMA Style

Pang X, Zhang Y, Wei H, Zhang J, Luo Q, Huang C, Zhang S. Expression and Effects of High-Mobility Group Box 1 in Cervical Cancer. International Journal of Molecular Sciences. 2014; 15(5):8699-8712.

Chicago/Turabian Style

Pang, Xiaoao; Zhang, Yao; Wei, Heng; Zhang, Jing; Luo, Qingshuang; Huang, Chenglin; Zhang, Shulan. 2014. "Expression and Effects of High-Mobility Group Box 1 in Cervical Cancer." Int. J. Mol. Sci. 15, no. 5: 8699-8712.


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