Special Issue "Inhibitors of Melanogenesis Related Processes: Application to Food and Cosmetic Industry"

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A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (31 March 2010)

Special Issue Editor

Guest Editor
Prof. Dr. Manickam Sugumaran
Department of Biology, University of Massachusetts Boston, 100 Morrissey Blvd, Boston, MA 02125, USA
E-Mail: manickam.sugumaran@umb.edu
Phone: +1 617 287 6598
Fax: +1 617 287 6650
Interests: enzymology; post translational modifications; aromatic metabolism; phenolic biochemistry; reactions of quinonoid compounds; invertebrate immunity; insect cuticular sclerotization; phenoloxidase; quinone isomerases; oxidative browning; melanin biosynthesis; catecholic antibiotics

Special Issue Information

Dear Colleagues,

Melanogenesis occurs ubiquitously in microorganism, plants and all animals. The enzyme tyrosinase also known as phenoloxidase initiates this process by hydroxylating monphenols to o-diphenols and further oxidizing o-diphenols to o-quinones. O-Quinones being unstable, undergo rapid nonenzymatic as well as enzyme catalyzed transformations to eventually produce different kinds of polymeric products. Quinones in general are very reactive and tend to deplete cellular antioxidant pools as well as cause deleterious effects on cellular macromolecules. In plants, such oxidative browning reactions reduce the nutritive values thereby helping the plant to cope up with infections and invasions. Oxidative browning certainly reduces the consume ability and hence their market value. The melanosis observed in crustaceans similarly reduces the market value of sea food drastically. In arthropods and especially insects, melanogenesis is used for wound healing and defense reactions. Mammals use melanin mostly as skin, coat and eye pigments. Therefore, prevention of oxidative browning of plant products as well as sea food, alteration of skin color, and prevention and/or reduction of melanogenesis in animals has great commercial potentials. This special edition will cover a broad range of phenoloxidase/tyrosinase chemistry, biochemistry of inhibitor and ways to develop new and novel natural and synthetic bioactive compounds against melanogenesis and related process.

Manickam Sugumaran
Guest Editor

Keywords

  • phenoloxidase inhibitors
  • tyrosinase inhibitors
  • inhibitors of melanogenesis
  • skin color lightening

Published Papers (9 papers)

Int. J. Mol. Sci. 2010, 11(7), 2699-2700; doi:10.3390/ijms11072699
Received: 5 July 2010; Accepted: 8 July 2010 / Published: 12 July 2010
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Int. J. Mol. Sci. 2010, 11(6), 2566-2575; doi:10.3390/ijms11062566
Received: 1 May 2010; in revised form: 9 June 2010 / Accepted: 10 June 2010 / Published: 18 June 2010
Show/Hide Abstract | Cited by 5 | PDF Full-text (105 KB) | HTML Full-text | XML Full-text

Int. J. Mol. Sci. 2010, 11(3), 1082-1089; doi:10.3390/ijms11031082
Received: 18 January 2010; Accepted: 3 March 2010 / Published: 12 March 2010
Show/Hide Abstract | Cited by 7 | PDF Full-text (468 KB) | HTML Full-text | XML Full-text

Int. J. Mol. Sci. 2009, 10(12), 5326-5349; doi:10.3390/ijms10125326
Received: 5 November 2009; in revised form: 24 November 2009 / Accepted: 9 December 2009 / Published: 10 December 2009
Show/Hide Abstract | Cited by 20 | PDF Full-text (166 KB) | HTML Full-text | XML Full-text

Int. J. Mol. Sci. 2009, 10(10), 4428-4434; doi:10.3390/ijms10104428
Received: 3 September 2009; in revised form: 29 September 2009 / Accepted: 9 October 2009 / Published: 15 October 2009
Show/Hide Abstract | Cited by 8 | PDF Full-text (120 KB) | HTML Full-text | XML Full-text

Int. J. Mol. Sci. 2009, 10(10), 4257-4266; doi:10.3390/ijms10104257
Received: 27 August 2009; in revised form: 22 September 2009 / Accepted: 24 September 2009 / Published: 29 September 2009
Show/Hide Abstract | Cited by 21 | PDF Full-text (78 KB) | HTML Full-text | XML Full-text
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Int. J. Mol. Sci. 2009, 10(9), 4066-4087; doi:10.3390/ijms10094066
Received: 21 August 2009; in revised form: 9 September 2009 / Accepted: 11 September 2009 / Published: 15 September 2009
Show/Hide Abstract | Cited by 20 | PDF Full-text (232 KB) | HTML Full-text | XML Full-text

Int. J. Mol. Sci. 2009, 10(9), 3811-3823; doi:10.3390/ijms10093811
Received: 5 August 2009; in revised form: 19 August 2009 / Accepted: 31 August 2009 / Published: 2 September 2009
Show/Hide Abstract | Cited by 17 | PDF Full-text (155 KB) | HTML Full-text | XML Full-text

Int. J. Mol. Sci. 2009, 10(6), 2440-2475; doi:10.3390/ijms10062440
Received: 21 April 2009; in revised form: 8 May 2009 / Accepted: 21 May 2009 / Published: 26 May 2009
Show/Hide Abstract | Cited by 153 | PDF Full-text (383 KB) | HTML Full-text | XML Full-text

Last update: 26 February 2014

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert