Int. J. Mol. Sci. 2009, 10(9), 4066-4087; doi:10.3390/ijms10094066
Review

Mechanisms Regulating Skin Pigmentation: The Rise and Fall of Complexion Coloration

Received: 21 August 2009; in revised form: 9 September 2009 / Accepted: 11 September 2009 / Published: 15 September 2009
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Skin pigmentary abnormalities are seen as aesthetically unfavorable and have led to the development of cosmetic and therapeutic treatment modalities of varying efficacy. Hence, several putative depigmenting agents aimed at modulating skin pigmentation are currently being researched or sold in commercially available products. In this review we will discuss the regulation of processes that control skin complexion coloration. This includes direct inhibition of tyrosinase and related melanogenic enzymes, regulation of melanocyte homeostasis, alteration of constitutive and facultative pigmentation and down-regulation of melanosome transfer to the keratinocytes. These various processes, in the complex mechanism of skin pigmentation, can be regulated individually or concomitantly to alter complexion coloration and thus ameliorate skin complexion diseases.
Keywords: depigmenting agents; hyperpigmentation; melanin; pigment; tyrosinase
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MDPI and ACS Style

Ebanks, J.P.; Wickett, R.R.; Boissy, R.E. Mechanisms Regulating Skin Pigmentation: The Rise and Fall of Complexion Coloration. Int. J. Mol. Sci. 2009, 10, 4066-4087.

AMA Style

Ebanks JP, Wickett RR, Boissy RE. Mechanisms Regulating Skin Pigmentation: The Rise and Fall of Complexion Coloration. International Journal of Molecular Sciences. 2009; 10(9):4066-4087.

Chicago/Turabian Style

Ebanks, Jody P.; Wickett, R. R.; Boissy, Raymond E. 2009. "Mechanisms Regulating Skin Pigmentation: The Rise and Fall of Complexion Coloration." Int. J. Mol. Sci. 10, no. 9: 4066-4087.

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