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Addendum: Quasi-Drugs Developed in Japan for the Prevention or Treatment of Hyperpigmentary Disorders. Int. J. Mol. Sci. 2010, 11, 2566–2575
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Addendum published on 12 July 2010, see Int. J. Mol. Sci. 2010, 11(7), 2699-2700.

Open AccessReview
Int. J. Mol. Sci. 2010, 11(6), 2566-2575; doi:10.3390/ijms11062566

Quasi-Drugs Developed in Japan for the Prevention or Treatment of Hyperpigmentary Disorders

1
Skin Aging and Photo-aging Research Center, Doshisha University, Kizugawa, Kyoto 619-0225, Japan
2
Kobe Skin Research Institute, Kobe, Hyogo 650-0047, Japan
3
Biological Research Division, The Estee Lauder Companies Inc., Melville, New York 11747, NY, USA
*
Author to whom correspondence should be addressed.
Received: 1 May 2010 / Revised: 9 June 2010 / Accepted: 10 June 2010 / Published: 18 June 2010
View Full-Text   |   Download PDF [105 KB, 19 June 2014; original version 19 June 2014]

Abstract

Excess production of melanin or its abnormal distribution, or both, can cause irregular hyperpigmentation of the skin, leading to melasma and age spots. To date, various quasi-drugs that prevent or improve hyperpigmentary disorders have been developed and officially approved by the Ministry of Health, Labor and Welfare of Japan. Many of these inhibit the activity of tyrosinase, an enzyme required for melanin synthesis, for example, by competitive or non-competitive inhibition of its catalytic activity, by inhibiting its maturation, or by accelerating its degradation. In this review, we categorize the quasi-drugs developed in Japan to prevent or treat hyperpigmentary disorders, or both, and discuss perspectives for future development.
Keywords: melanin; melanocyte; pigmentation; skin melanin; melanocyte; pigmentation; skin
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Ando, H.; Matsui, M.S.; Ichihashi, M. Quasi-Drugs Developed in Japan for the Prevention or Treatment of Hyperpigmentary Disorders. Int. J. Mol. Sci. 2010, 11, 2566-2575.

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