An addendum was published on 12 July 2010, see Int. J. Mol. Sci. 2010, 11(7), 2699-2700.

Int. J. Mol. Sci. 2010, 11(6), 2566-2575; doi:10.3390/ijms11062566
Review

Quasi-Drugs Developed in Japan for the Prevention or Treatment of Hyperpigmentary Disorders

Received: 1 May 2010; in revised form: 9 June 2010 / Accepted: 10 June 2010 / Published: 18 June 2010
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Excess production of melanin or its abnormal distribution, or both, can cause irregular hyperpigmentation of the skin, leading to melasma and age spots. To date, various quasi-drugs that prevent or improve hyperpigmentary disorders have been developed and officially approved by the Ministry of Health, Labor and Welfare of Japan. Many of these inhibit the activity of tyrosinase, an enzyme required for melanin synthesis, for example, by competitive or non-competitive inhibition of its catalytic activity, by inhibiting its maturation, or by accelerating its degradation. In this review, we categorize the quasi-drugs developed in Japan to prevent or treat hyperpigmentary disorders, or both, and discuss perspectives for future development.
Keywords: melanin; melanocyte; pigmentation; skin
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MDPI and ACS Style

Ando, H.; Matsui, M.S.; Ichihashi, M. Quasi-Drugs Developed in Japan for the Prevention or Treatment of Hyperpigmentary Disorders. Int. J. Mol. Sci. 2010, 11, 2566-2575.

AMA Style

Ando H, Matsui MS, Ichihashi M. Quasi-Drugs Developed in Japan for the Prevention or Treatment of Hyperpigmentary Disorders. International Journal of Molecular Sciences. 2010; 11(6):2566-2575.

Chicago/Turabian Style

Ando, Hideya; Matsui, Mary S.; Ichihashi, Masamitsu. 2010. "Quasi-Drugs Developed in Japan for the Prevention or Treatment of Hyperpigmentary Disorders." Int. J. Mol. Sci. 11, no. 6: 2566-2575.

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