Special Issue "Bioactive Carbohydrates and Peptides"
Deadline for manuscript submissions: 30 November 2014
Dr. Brijesh Tiwari
Department of Food Biosciences, Teagasc Food Research Centre, Ashtown, Dublin 15, Ireland
Phone: +353 (0) 1 8059785
Fax: +353 (0) 1 8059550
Bioactive compounds are a heterogeneous group of substances found in all foods, thus constituting an important component of the human diet. Consumption of food rich in bioactives has been reported to protect against some degenerative diseases that affect humans. Bioactive carbohydrates and peptides have attracted considerable interest among researchers and consumers due to their biofunctional and technofunctional properties. Extraction, isolation and characterization of bioactive carbohydrates and peptides from new matrices (e.g. marine bioresources), underutilized plants and food processing waste, provide an opportunity to source bioactive carbohydrates and peptides as a functional ingredient.
This Special Issue will focus on various aspects of extraction, isolation, characterization and application of bioactive carbohydrates and peptides from various sources, including novel and existing sources. This Special Issue therefore invites original, unpublished research and review contributions on:
- Biochemical and biofunctional properties of bioactive carbohydrates and peptides.
- Impact of processing and extraction technologies on properties.
- Recent advances in analytical and extraction techniques for bioactive carbohydrates and peptides.
- Novel industrial and nutraceutical applications of bioactive carbohydrates and peptides.
- High throughput screening bioactive carbohydrates and peptides from novel marine bioresources, underutilized plants and food processing waste.
- Structure—functional relationship, biochemical pathway and degradation mechanisms.
Dr. Brijesh Tiwari
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed Open Access monthly journal published by MDPI.
- bioactive carbohydrates
- bioactive peptides
- marine bio-resources
- extraction technologies
- functional properties and characterization
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: The PI3K/Akt1-FoxO1 translocation pathway mediates EXf effects
on NIT-1 cell survival
Authors: Zhufang Shen et al.
Affiliation: Chinese Academy of Medical Sciences & Peking Union Medical College, China
Abstract: EXf, a glucagon-like peptide 1 (GLP-1) receptor agonist, stimulates β-cell proliferation and reduces apoptosis in diabetic animal models, but the underlying mechanisms are not fully understood. We constructed a FoxO1-GFP fusion protein expression plasmid and transiently transfected it into NIT-1 cells to investigate whether FoxO1 mediates EXf effects on NIT-1 cell survival. Our results showed that EXf could increase cell viability and promote the translocation of the FoxO1-GFP fusion protein from the nucleus to the cytoplasm in NIT-1 cells. In addition, the FoxO1 nuclear exclusion effect of EXf was suppressed by Wortmannin, an inhibitor of PI3K. Comparative transcription analysis showed up-regulation of igf-1r, irs-2, pI3k, akt1 and pdx-1 in NIT-1 cells after EXf treatment. Moreover, the up-regulation of PI3K and phosphorylation of Akt1 upon EXf treatment was confirmed by Western blot, both phenomena were abrogated by wortmannin. In summary, FoxO1 may mediate the effects of EXf on NIT-1 cell survival by activating the PI3K/ Akt1 pathway.
Title: Role of Aeromonas hydrophila flagella glycosylation in adhesion to Hep-2 cells, biofilm formation and immune stimulation
Authors: Juan M. Tomás et al.
Affiliation: University of Barcelona, Spain
Abstract: Polar flagellin proteins from Aeromonas hydrophila strain AH-3 (serotype O34) were found to be O-glycosylated with a heterogeneous heptasaccharide glycan. Two mutants with altered (light and strong) polar flagella glycosylation still able to produce flagella were previously obtained, as well as mutants lacking the O34-antigen LPS but with unaltered polar flagella glycosylation. We compared these mutants, altogether with the wild type strain, in different studies to conclude that polar flagella glycosylation is extremely important for A. hydrophila adhesion to Hep-2 cells and biofilm formation. Furthermore, the polar flagella glycosylation is an important factor for the immune stimulation of IL-8 production via TLR5.
Last update: 29 August 2014