Cellular Disulfide Bond Formation in Bioactive Peptides and Proteins
AbstractBioactive peptides play important roles in metabolic regulation and modulation and many are used as therapeutics. These peptides often possess disulfide bonds, which are important for their structure, function and stability. A systematic network of enzymes—a disulfide bond generating enzyme, a disulfide bond donor enzyme and a redox cofactor—that function inside the cell dictates the formation and maintenance of disulfide bonds. The main pathways that catalyze disulfide bond formation in peptides and proteins in prokaryotes and eukaryotes are remarkably similar and share several mechanistic features. This review summarizes the formation of disulfide bonds in peptides and proteins by cellular and recombinant machinery. View Full-Text
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Patil, N.A.; Tailhades, J.; Hughes, R.A.; Separovic, F.; Wade, J.D.; Hossain, M.A. Cellular Disulfide Bond Formation in Bioactive Peptides and Proteins. Int. J. Mol. Sci. 2015, 16, 1791-1805.
Patil NA, Tailhades J, Hughes RA, Separovic F, Wade JD, Hossain MA. Cellular Disulfide Bond Formation in Bioactive Peptides and Proteins. International Journal of Molecular Sciences. 2015; 16(1):1791-1805.Chicago/Turabian Style
Patil, Nitin A.; Tailhades, Julien; Hughes, Richard A.; Separovic, Frances; Wade, John D.; Hossain, Mohammed A. 2015. "Cellular Disulfide Bond Formation in Bioactive Peptides and Proteins." Int. J. Mol. Sci. 16, no. 1: 1791-1805.