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Int. J. Mol. Sci. 2015, 16(1), 1791-1805; doi:10.3390/ijms16011791

Cellular Disulfide Bond Formation in Bioactive Peptides and Proteins

1
Florey Institute of Neuroscience and Mental Health, the University of Melbourne, Victoria 3010, Australia
2
School of Chemistry, the University of Melbourne, Victoria 3010, Australia
3
Department of Pharmacology and Therapeutics, the University of Melbourne, Victoria 3010, Australia
4
Florey Departments of Neuroscience and Mental Health, the University of Melbourne, Victoria 3010, Australia
*
Author to whom correspondence should be addressed.
Academic Editor: Brijesh Tiwari
Received: 24 November 2014 / Accepted: 2 January 2015 / Published: 14 January 2015
(This article belongs to the Special Issue Bioactive Carbohydrates and Peptides)
View Full-Text   |   Download PDF [1358 KB, uploaded 14 January 2015]   |  

Abstract

Bioactive peptides play important roles in metabolic regulation and modulation and many are used as therapeutics. These peptides often possess disulfide bonds, which are important for their structure, function and stability. A systematic network of enzymes—a disulfide bond generating enzyme, a disulfide bond donor enzyme and a redox cofactor—that function inside the cell dictates the formation and maintenance of disulfide bonds. The main pathways that catalyze disulfide bond formation in peptides and proteins in prokaryotes and eukaryotes are remarkably similar and share several mechanistic features. This review summarizes the formation of disulfide bonds in peptides and proteins by cellular and recombinant machinery. View Full-Text
Keywords: bioactive peptides; disulfide bonds; peptide and protein folding; oxidative folding; recombinant technology bioactive peptides; disulfide bonds; peptide and protein folding; oxidative folding; recombinant technology
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Patil, N.A.; Tailhades, J.; Hughes, R.A.; Separovic, F.; Wade, J.D.; Hossain, M.A. Cellular Disulfide Bond Formation in Bioactive Peptides and Proteins. Int. J. Mol. Sci. 2015, 16, 1791-1805.

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